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The Dieulafoy lesion is a rare cause of severe upper gastrointestinal bleeding associated with a significant mortality. Rebleeding from undiscovered lesions is frequent and often fatal. The outcome depends on a high degree of suspicion for the condition. In any age group, the entity may be underdiagnosed rather than truly rare. It is particularly uncommon(More)
BACKGROUND & AIMS Cystic fibrosis (CF) is caused by over 1000 mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and presents with a widely variable phenotype. Genotype-phenotype studies identified CFTR mutations that were associated with pancreatic sufficiency (PS). Residual Cl- channel function was shown for selected PS(More)
Kindlin-1 is an epithelium-specific phosphoprotein and focal adhesion adaptor component. Mutations in the corresponding gene (KIND1) cause Kindler syndrome (KS), which is manifested by skin blistering, poikiloderma, photosensitivity and carcinogenesis. Some patients also exhibit gastrointestinal symptoms, but it has remained unclear whether these represent(More)
Antioxidants such as vitamin E protect unsaturated fatty acids of LDL against oxidation. In the ex vivo model used, LDL was exposed to Cu2+ ions, a potent prooxidant capable of initiating the oxidation of LDL. The lag time, indicating the delay of conjugated diene formation in LDL due to antioxidant protection, was measured in 54 cystic fibrosis (CF)(More)
The torsion and infarction of an accessory spleen must be considered as a rare cause of acute abdominal pain in childhood. It can be accompanied by acute diffuse or localised abdominal pain and it could also appear to be an acute appendicitis or an intussusception. The ultrasound examination helps to narrow down the possible differential diagnoses.
The Grusin operator ∆G = 1 2 (∂ 2 x + x 2 ∂ 2 y), x, y ∈ R, is studied by Hamilton-Jacobi theory. In particular, we find all the geodesics of ∆G of the induced nonholonomic geometry, construct a modified complex action f which allows us to obtain the heat kernel Pt of ∆G. The small time asymptotics of Pt at all critical points of f are computed. Finally we(More)