Peter F. Crookes

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INTRODUCTION Obesity and gastroesophageal reflux disease (GERD) are increasingly important health problems. Previous studies of the relationship between obesity and GERD focus on indirect manifestations of GERD. Little is known about the association between obesity and objectively measured esophageal acid exposure. The aim of this study is to quantify the(More)
BACKGROUND It has been suggested that endoscopic grading of the gastroesophageal flap valve is a good predictor of the reflux status. METHODS To test this hypothesis, 268 symptomatic patients underwent endoscopic grading of the gastroesophageal valve using Hill's classification, with grades I through IV. Esophageal acid exposure, lower esophageal(More)
HYPOTHESIS There is an independent association between the different patterns of esophageal acid exposure in gastroesophageal reflux disease and the severity of the disease. DESIGN Case-comparison study. SETTING Department of surgery at a university hospital. PATIENTS A group of 401 patients with increased esophageal acid exposure divided into 4(More)
OBJECTIVE The objective of this study was to establish normative ambulatory manometric data for contractions and contraction propagation in three levels of the esophagus. METHODS Twenty-five healthy volunteers underwent simultaneous ambulatory 24 h manometry. Concomitant 24 h pH studies were performed to exclude the presence of increased esophageal acid(More)
HYPOTHESIS Measurement of pancreatic polypeptide (PP) response to sham feeding and pharmacological stimulation is a safe, noninvasive, and sensitive test for vagal integrity. DESIGN Interventional study with control arms. SETTING Tertiary center for esophageal surgery. PATIENTS Thirty healthy volunteers and 25 patients who underwent total(More)
Five different tests were used to evaluate oesophageal function in 22 patients who presented to a cardiac unit with acute chest pain but whose cardiological investigations were negative. Eight patients had an abnormality on oesophagoscopy, 10 had an abnormal pH monitoring study, six had a positive acid infusion test, 10 had an abnormal manometric study and(More)
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