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Prostate cancer, a leading cause of cancer death, displays a broad range of clinical behavior from relatively indolent to aggressive metastatic disease. To explore potential molecular variation underlying this clinical heterogeneity, we profiled gene expression in 62 primary prostate tumors, as well as 41 normal prostate specimens and nine lymph node(More)
CONTEXT The epidemiological evidence that fatty fish consumption may be associated with the lower risk of several cancers is not consistent and no studies of renal cell carcinoma (RCC) exist. OBJECTIVE To examine the association between fatty and lean fish consumption and risk of RCC in women. DESIGN, SETTING, AND PARTICIPANTS The Swedish Mammography(More)
In an allelotyping study prostatic carcinoma, we found the highest frequency of allelic deletions on chromosomes 8, 10, 16, and 18. In all cases with allelic deletions, at least one of the chromosomes 8, 10, and 16 were involved. A detailed deletion mapping of these chromosomes in 18 cases was carried out with probes that detect restriction fragment length(More)
  • P Ekman
  • 1994
Finasteride acts by blocking the conversion of testosterone to 5 alpha-dihydrotestosterone, the active androgen metabolite in the human prostate. In large, double-blind, placebo-controlled phase III studies recruiting over 1600 patients, it was shown that the administration of Finasteride, either 5 or 1 mg a day, reduced the size of the prostate by a mean(More)
Interstitial cystitis (IC) is a painful condition in the urinary bladder of unknown aetiology and pathogenesis. To assess the contribution of the nervous system to IC a biopsy was taken from 6 patients with IC and from a control group of 6 patients with non-ulcerative IC. Mast cells were counted and histamine measured in bladder washings from all patients.(More)
PURPOSE We compared the efficacy and toxicity of long-term mitomycin C versus bacillus Calmette-Guerin (BCG) instillation in patients at high risk for recurrence and progression of superficial bladder carcinoma. MATERIALS AND METHODS Our randomized comparison study included 261 patients with primary dysplasia, or stage Tis, stage T1, grade 3 and multiple(More)
Cadherins (CDH) are cell adhesion molecules and their dysfunctions have been implicated in the development of cancer metastases. Several cadherin genes are tandemly located on 16q, which is frequently deleted in prostate cancer. We therefore used 22 markers on 16q to localize important deleted regions in metastases of this tumor. We found 16q deletions in(More)
Either transurethral ureteroscopy (URS) or extracorporeal shock wave lithotripsy (ESWL) was the primary method of intervention in two series of patients presenting consecutively with stones located in the ureter distal to the radiological marking of the sacroiliac joint. Of 65 patients treated by URS, successful evacuation of the major part of the stone was(More)
Discs of urinary catheters with different coatings were exposed to a flow of artificial urine containing cells of Pseudomonas aeruginosa. Within 10 h an adherent biofilm consisting of the bacteria and their exopolysaccharide products had developed on those discs coated with latex, teflon, and silicon. In contrast, on the silver alloy-coated catheter discs(More)