Peter E Waldron

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BACKGROUND Acute chest syndrome (ACS) is the leading cause of hospitalization, morbidity, and mortality in patients with sickle cell disease. Radiographic and clinical findings in ACS resemble pneumonia; however, etiologies other than infectious pathogens have been implicated, including pulmonary fat embolism (PFE) and infarction of segments of the(More)
Acute myeloid leukemia (AML) is a heterogeneous group of diseases that differ in pattern of both remission and lineage involvement. The observation that hematopoiesis remains clonal in some patients with AML in complete clinical remission suggests that the acute phase may develop from a clinically unrecognized preleukemic clone. To investigate the(More)
Membranes were isolated from Escherichia coli and treated with cold 90% aqueous acetone to remove neutral lipids and phospholipids. This treatment resulted in the loss of more than 90% of o-lactate, NADH, and succinate oxidase activities. The activities could be restored to the lipid-depleted particles by preincubation, for 3 min at 37”, with a dispersion(More)
Cardio-facio-cutaneous syndrome (CFC) and Costello syndrome (CS) are disorders with an overlapping spectrum of congenital anomalies. Mutations in the RAS-MAPK pathway have recently been reported in both of these syndromes, with HRAS mutations characteristic for CS and BRAF and MEK1/2 mutations for CFC. We report on a 3-year-old boy who underwent a cardiac(More)
UNLABELLED PURPOSE Few studies address the association of Chlamydia pneumoniae infection with pulmonary disease and outcome in patients with underlying pathology such as sickle cell disease (SCD). SCD patients are susceptible to the pulmonary disorder known as acute chest syndrome (ACS), where the etiology remains ill defined. The purpose of this study was(More)
A C EMOPHILIA A IS A bleeding diathesis caused by factor VIII (FVIII) deficiency. It may be complicated by inhibtors which are auto antibodies to FVIII.1 Recombinant actiated factor VII (rFVIIa) is a potent hemostatic agent approved y the Food and Drug Administration for use in hemophiliacs ith inhibitors. A case in which rFVIIa was used for the uccessful(More)
Central nervous system hemorrhages are an uncommon but severe complication of hemophilia, occurring in only 2-8% of children with hemophilia. Less than 10% of these CNS hemorrhages are intraspinal. The authors report on their care of an infant with hemophilia A who presented with irritability, meningismus, and decreased spontaneous movement. These symptoms(More)
Recombinant human granulocyte-macrophage (GM) colony-stimulating factor (GM-CSF), G-CSF, and interleukin-3 (IL-3) labeled with 125I were used to study the characteristics and distribution of receptors for these factors on in vitro cell lines and on cells from patients with acute nonlymphocytic leukemia (ANL) and acute lymphocytic leukemia (ALL). Receptors(More)
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