Peter Doran

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Efforts aimed at deciphering the molecular basis of complex disease are underpinned by the availability of high throughput strategies for the identification of biomolecules that drive the disease process. The completion of the human genome-sequencing project, coupled to major technological developments, has afforded investigators myriad opportunities for(More)
BACKGROUND The use of Clinical Data Management Systems (CDMS) has become essential in clinical trials to handle the increasing amount of data that must be collected and analyzed. With a CDMS trial data are captured at investigator sites with "electronic Case Report Forms". Although more and more of these electronic data management systems are used in(More)
ENDURANCE (Environmentally Non-Disturbing Under-ice Robotic Antarctic Explorer) is a highly maneuverable, hovering autonomous underwater science platform descended from the DEPTHX vehicle, both of which were developed under NASA ASTEP funding. ENDURANCE had the specifi c mission of descending through a 5 meter deep melt hole in the ice cap of West Lake(More)
As has been exemplified by recent progress in the classification of cancer, future approaches to enhance the clinical diagnostic power of tissue biopsies may be based on gene expression profiles. A series of strategies to translate these approaches to the diagnosis of renal disease is here proposed. The theoretical and technical problems resulting from the(More)
The ENDURANCE autonomous underwater vehicle was developed and deployed to explore and map a unique environment: the waters of Lake Bonney in Taylor Valley, one of the McMurdo Dry Valleys of Antarctica. This permanently ice-covered lake presented several unique challenges and opportunities for exploration and mapping with an AUV. ENDURANCE was successfully(More)
BACKGROUND Hypertrophic cardiomyopathy (HCM) is a genetic condition, and relatives of affected persons may be at risk. Cardiac troponin biomarkers have previously been shown to be elevated in HCM. This study examines the new highly-sensitive cardiac troponin I (hsTnI) assay in a HCM screening population. METHODS Nested case-control study of consecutive(More)
INTRODUCTION Neuroepithelial Transforming Gene 1 (NET1) is a well characterised oncoprotein and a proven marker of an aggressive phenotype in a number of cancers, including gastric adenocarcinoma. We aimed to investigate whether NET1 plays a functional role in oesophageal cancer (OAC) and its pre-malignant phenotype Barrett's oesophagus. METHODS Baseline(More)
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