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SUMMARY The theoretical principles and practical implementation of a new method for multivariate data analysis, maximum likelihood principal component analysis (MLPCA), are described. MLCPA is an analog to principal component analysis (PCA) that incorporates information about measurement errors to develop PCA models that are optimal in a maximum likelihood… (More)

- M Juanita Martinez, Sushmita Roy, +7 authors Margaret Werner-Washburne
- Molecular biology of the cell
- 2004

Most cells on earth exist in a quiescent state. In yeast, quiescence is induced by carbon starvation, and exit occurs when a carbon source becomes available. To understand how cells survive in, and exit from this state, mRNA abundance was examined using oligonucleotide-based microarrays and quantitative reverse transcription-polymerase chain reaction. Cells… (More)

The application of a new method to the multivariate analysis of incomplete data sets is described. The new method, called maximum likelihood principal component analysis (MLPCA), is analogous to conventional principal component analysis (PCA), but incorporates measurement error variance information in the decomposition of multivariate data. Missing… (More)

- Peter D. Wentzell, Lorenzo Vega Montoto
- 2003

Two of the most widely employed multivariate calibration methods, principal components regression (PCR) and partial least squares regression (PLS), are compared using simulation studies of complex chemical mixtures which contain a large number of components. Details of the complex mixture model, including concentration distributions and spectral… (More)

- Peter D. Wentzell, Mitchell T. Lohnes
- 1997

Procedures to compensate for correlated measurement errors in multivariate data analysis are described. These procedures Ž. are based on the method of maximum likelihood principal component analysis MLPCA , previously described in the literature. MLPCA is a decomposition method similar to conventional PCA, but it takes into account measurement uncertainty… (More)

- P D Wentzell, D T Andrews, B R Kowalski
- Analytical chemistry
- 1997

Two new approaches to multivariate calibration are described that, for the first time, allow information on measurement uncertainties to be included in the calibration process in a statistically meaningful way. The new methods, referred to as maximum likelihood principal components regression (MLPCR) and maximum likelihood latent root regression (MLLRR),… (More)

Algorithms for carrying out maximum likelihood parallel factor analysis (MLPARAFAC) for three-way data are described. These algorithms are based on the principle of alternating least squares, but differ from conventional PARAFAC algorithms in that they incorporate measurement error information into the trilinear decomposition. This information is… (More)

- Peter D. Wentzell, Tobias K. Karakach, Sushmita Roy, M. Juanita Martinez, Christopher P. Allen, Margaret Werner-Washburne
- BMC Bioinformatics
- 2006

BACKGROUND
Modeling of gene expression data from time course experiments often involves the use of linear models such as those obtained from principal component analysis (PCA), independent component analysis (ICA), or other methods. Such methods do not generally yield factors with a clear biological interpretation. Moreover, implicit assumptions about the… (More)

—The transmittance spectra of a long-period fiber grating element immersed in different mixtures of water and dimethyl sulfoxide were recorded. The obtained data were compared with a theoretical model based on linearly polarized modes treated with a coupled-mode approach. Excellent agreement between the measurements and theoretical results was found over a… (More)

- P D Wentzell, S S Nair, R D Guy
- Analytical chemistry
- 2001

The application of trilinear decomposition (TLD) to the analysis of fluorescence excitation-emission matrices of mixtures of polycyclic aromatic hydrocarbons (PAHs) is described. The variables constituting the third-order tensor are excitation wavelength, emission wavelength, and concentration of a fluorescence quencher (nitromethane). The addition of a… (More)