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BACKGROUND Tobacco smoking is associated with chronic obstructive pulmonary disease (COPD) in more than 80% of cases. Our aim was to investigate the effect of sustained-release bupropion (amfebutamone) (SR) in promoting abstinence from smoking in patients with COPD. METHODS In a double-blind, randomised, placebo-controlled trial 404 individuals with mild(More)
This paper reviews the evidence for the effectiveness and cost-effectiveness of policies and programmes to reduce the harm caused by alcohol, in the areas of education and information, the health sector, community action, driving while under the influence of alcohol (drink-driving), availability, marketing, pricing, harm reduction, and illegally and(More)
BACKGROUND The European level of alcohol consumption, and the subsequent burden of disease, is high compared to the rest of the world. While screening and brief interventions in primary healthcare are cost-effective, in most countries they have hardly been implemented in routine primary healthcare. In this study, we aim to examine the effectiveness and(More)
During 1971-77 the incidence of bacterial meningitis among Alaskan Eskimos was 84.4 cases per 100 000 population per year, which is more than 10 times that for most other U.S. populations. Haemophilus influenzae (HI) accounted for 68% of meningitis cases. The average annual incidence of HI disease per 100 000 children below 5 years of age was 409 for(More)
PURPOSE OF REVIEW The WHO is preparing its global strategy on alcohol, and, in so doing, has been asked to consult with the alcohol industry on ways it could contribute in reducing the harm done by alcohol. This review asks which is more effective in reducing harm: the regulatory approaches that the industry does not favour; or the educational approaches(More)
The cone snail is a marine predatory snail that uses powerful venom to kill its prey [1]. Conotoxins are a group of cysteine-rich peptide-based toxins in the venom of cone snails [2]. Most conotoxins contain multiple disulfide bridges. Secondary uses of conotoxins by the snails are protection against predators and competitors. Conotoxins are considered by(More)
The attainment of quality in general practice entails explicit recognition of the public-health content of primary care. General practitioners should accept responsibility for auditing the state of the practice health, monitoring and controlling environmental disease, planning local services, auditing the effectiveness of preventive programmes, and(More)
BACKGROUND Brief interventions in primary healthcare are cost-effective in reducing drinking problems but poorly implemented in routine practice. Although evidence about implementing brief interventions is growing, knowledge is limited with regard to impact of initial role security and therapeutic commitment on brief intervention implementation. METHODS(More)
AIMS The aim of the study was to assess the cumulative evidence on the effectiveness of brief alcohol interventions in primary healthcare in order to highlight key knowledge gaps for further research. METHODS An overview of systematic reviews and meta-analyses of the effectiveness of brief alcohol intervention in primary healthcare published between 2002(More)