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Life and death fate decisions allow cells to avoid massive apoptotic death in response to genotoxic stress. Although the regulatory mechanisms and signalling pathways controlling DNA repair and apoptosis are well characterized, the precise molecular strategies that determine the ultimate choice of DNA repair and survival or apoptotic cell death remain(More)
The temporal and spatial patterns of accumulation of transcripts from individual actin genes during Drosophila embryogenesis have been determined by in situ hybridization. We describe the subcloning into transcription vectors of unique DNA fragments derived from the 3' transcribed, but nontranslated region of each actin gene. These fragments then served as(More)
The Software Technology Program of MCC is investigating the early part of the design process, before requirements are established, for large-scale distributed systems. Face-to-face meetings are an important activity during this phase of a project since they provide a medium for direction, exploration, and consensus building. Project Nick is attempting to(More)
We discuss the development and calibration of a model for predicting seepage into underground openings. Seepage is a key factor affecting the performance of the potential nuclear-waste repository at Yucca Mountain, Nevada. Three-dimensional numerical models were developed to simulate field tests in which water was released from boreholes above excavated(More)
The hypnotic and residual sedative effects of the first and seventh of seven regular night-time doses of nitrazepam 5 mg, temazepam 20 mg, and placebo were studied in 58 elderly inpatients. Plasma temazepam and nitrazepam concentrations rose by about 50% and 113% respectively between the mornings of day 1 and day 7. Patients reported sleeping well more(More)