Peter C. Doherty

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Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

William E. Thierfelder, Jan M. A. van Deursen, +8 authors James N. Ihle
Nature
1996

SIGNAL transducers and activators of transcription (STATs) are activated by tyrosine phosphorylation in response to cytokines and mediate many of their functional responses1–3. Stat4 was initially… (More)

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

Kazuya Shimoda, Jan van Deursent, +11 authors James N. Ihle
Nature
1996

SIGNAL transducers and activators of transcription (Stats) are activated by tyrosine phosphorylation in response to cytokines, and are thought to mediate many of their functional responses1–4. Stat6… (More)

Virus-specific CD8+ T cells in primary and secondary influenza pneumonia.

Kirsten J. Flynn, Gabrielle T. Belz, John D Altman, Rafi Ahmed, David L. Woodland, Peter C. Doherty
Immunity
1998

Virus-specific CD8+ effector T cells (eCTL) are enriched in the lungs of mice with primary influenza pneumonia, though later detection of memory T cells (mCTL) in the mediastinal lymph nodes (MLN) or… (More)

Progressive Loss of Cd8 + T Cell-mediated Control of a ~/-herpesvirus in the Absence of Cd4 + T Cells

David J. Cardin, James W. Brooks, K. Sarawar, Peter C. Doherty
1996

A unique experimental model has been developed for dissecting the integrity of CD8 + T cellmediated immunity to a persistent gammaherpesvirus under conditions of CD4 + T cell deficiency. Respiratory… (More)

CD8+ T cells clear influenza virus by perforin or Fas-dependent processes.

David J. Topham, Ralph A Tripp, Peter C. Doherty
Journal of immunology
1997

Influenza virus infection is controlled in CD4-depleted mice that are also defective for the expression of either Fas (Fas-/-) or perforin (P-/-). Virus-immune P+/+ and P-/- CD8+ T cells can thus… (More)

Altered peptidase and viral-specific T cell response in LMP2 mutant mice.

Luc Van Kaer, Philip G. Ashton-Rickardt, +6 authors Susumu Tonegawa
Immunity
1994

MHC class I molecules present peptides generated by processing of endogenously synthesized proteins to CD8+ T lymphocytes. Recently, large proteolytic complexes, termed proteasomes, were implicated… (More)

The collagen binding alpha1beta1 integrin VLA-1 regulates CD8 T cell-mediated immune protection against heterologous influenza infection.

Steven J Ray, Suzanne N Franki, +6 authors David J. Topham
Immunity
2004

A common feature of many infections is that many pathogen-specific memory T cells become established in diverse nonlymphoid tissues. A mechanism that promotes the retention and survival of the memory… (More)

Pathogenesis of an Infectious Mononucleosis-like Disease Induced by a Murine γ-Herpesvirus: Role for a Viral Superantigen?

Ralph A Tripp, Ann Marie Hamilton-Easton, +5 authors Marcia A Blackman
The Journal of experimental medicine
1997

The murine gamma-herpesvirus 68 has many similarities to EBV, and induces a syndrome comparable to infectious mononucleosis (IM). The frequency of activated CD8+ T cells (CD62L(lo)) in the peripheral… (More)

Enhanced immunological surveillance in mice heterozygous at the H-2 gene complex

Peter C. Doherty, Rolf Martin Zinkernagel
Nature
1975

THE major histocompatibility (H) antigens of higher animals show extreme genetic polymorphism equalled, in higher vertebrates, only by that associated with the immunoglobulins1. Maintenance of such a… (More)

Cellular events in the lymph node and lung of mice with influenza. Consequences of depleting CD4+ T cells.

William Allan, Z Tabi, Angela M Cleary, Peter C. Doherty
Journal of immunology
1990

The cellularity of the mediastinal lymph nodes of mice infected intranasally with a high dose of an H3N2 influenza A virus increases massively within 5 days. All classes of lymphocytes are involved.… (More)

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