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OBJECTIVES To determine the effect of long term inhaled corticosteroids on lung function, exacerbations, and health status in patients with moderate to severe chronic obstructive pulmonary disease. DESIGN Double blind, placebo controlled study. SETTING Eighteen UK hospitals. PARTICIPANTS 751 men and women aged between 40 and 75 years with mean forced(More)
The first series of three workers who developed occupational asthma following exposure to airborne chloramines in indoor chlorinated swimming pools is reported. Health problems of swimmers in indoor pools have traditionally been attributed to the chlorine in the water. Chlorine reacts with bodily proteins to form chloramines; the most volatile and prevalent(More)
BACKGROUND Clinical studies suggest that inhaled corticosteroids reduce exacerbations and improve health status in chronic obstructive pulmonary disease (COPD). However, their effect on mortality is unknown. METHODS A pooled analysis, based on intention to treat, of individual patient data from seven randomised trials (involving 5085 patients) was(More)
Nitrogen dioxide is a common indoor pollutant. In the light of suggestions that outdoor air pollution can harm people with asthma, we investigated the effect of 1 h exposures to domestic concentrations of nitrogen dioxide on the airway response to house-dust mite (HDM) allergen in ten patients with mild asthma. Each subject breathed air, 100 ppb nitrogen(More)
BACKGROUND Exposure to metal working fluid (MWF) has been associated with outbreaks of extrinsic allergic alveolitis (EAA) in the USA, with bacterial contamination of MWF being a possible cause, but is uncommon in the UK. Twelve workers developed EAA in a car engine manufacturing plant in the UK, presenting clinically between December 2003 and May 2004.(More)
PURPOSE The purpose of this study was to determine the relationships between split times within sprint tests over 30 m and 40 m in elite Australian Rules footballers. METHODS Data were analyzed from two Australian Football League (AFL) clubs. The first club (n = 35) conducted a 40-m sprint test and recorded split times at 10 m and 20 m. The second club (n(More)
This product is part of the RAND Europe working paper series. RAND working papers are intended to share researchers' latest findings and to solicit informal peer review. They have been approved for circulation by RAND Europe but have not been formally edited or peer reviewed. Unless otherwise indicated, working papers can be quoted and cited without(More)
BACKGROUND Occupational asthma is the most frequently reported work related respiratory disease in many countries. This work was commissioned by the British Occupational Health Research Foundation to assist the Health and Safety Executive in achieving its target of reducing the incidence of occupational asthma in Great Britain by 30% by 2010. AIM The(More)
This paper discusses the status of research on detection of fraud undertaken as part of the European Commission-funded ACTS ASPeCT (Advanced Security for Personal Communications Technologies) project. A first task has been the identification of possible fraud scenarios and of typical fraud indicators which can be mapped to data in toll tickets. Currently,(More)