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Novel antifungal α-hairpinin peptide from Stellaria media seeds: structure, biosynthesis, gene structure and evolution
Plant defense against disease is a complex multistage system involving initial recognition of the invading pathogen, signal transduction and activation of specialized genes. An important role inExpand
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Buckwheat trypsin inhibitor with helical hairpin structure belongs to a new family of plant defence peptides.
A new peptide trypsin inhibitor named BWI-2c was obtained from buckwheat (Fagopyrum esculentum) seeds by sequential affinity, ion exchange and reversed-phase chromatography. The peptide was sequencedExpand
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Structural Similarity between Defense Peptide from Wheat and Scorpion Neurotoxin Permits Rational Functional Design*
Background: Protein folds differ in size and complexity and hence in their utility for engineering purposes. Results: The three-dimensional structure of wheat antifungal peptide Tk-AMP-X2 wasExpand
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Genes encoding 4‐Cys antimicrobial peptides in wheat Triticum kiharae Dorof. et Migush.: multimodular structural organization, instraspecific variability, distribution and role in defence
A novel family of antifungal peptides was discovered in the wheat Triticum kiharae Dorof. et Migusch. Two members of the family, designated Tk‐AMP‐X1 and Tk‐AMP‐X2, were completely sequenced andExpand
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Modular toxin from the lynx spider Oxyopes takobius: Structure of spiderine domains in solution and membrane‐mimicking environment
We have recently demonstrated that a common phenomenon in evolution of spider venom composition is the emergence of so‐called modular toxins consisting of two domains, each corresponding to a “usual”Expand
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Scorpion toxins interact with nicotinic acetylcholine receptors
Neurotoxins are among the main components of scorpion and snake venoms. Scorpion neurotoxins affect voltage‐gated ion channels, while most snake neurotoxins target ligand‐gated ion channels, mainlyExpand
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Structure of purotoxin-2 from wolf spider: modular design and membrane-assisted mode of action in arachnid toxins.
Traditionally, arachnid venoms are known to contain two particularly important groups of peptide toxins. One is disulfide-rich neurotoxins with a predominance of β-structure that specifically targetExpand
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Protein surface topography as a tool to enhance the selective activity of a potassium channel blocker
Tk-hefu is an artificial peptide designed based on the α-hairpinin scaffold, which selectively blocks voltage-gated potassium channels Kv1.3. Here we present its spatial structure resolved by NMRExpand
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NMR spatial structure of Tk-hefu peptide
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