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Software system faults are often caused by unexpected interactions among components. Yet the size of a test suite required to test all possible combinations of interactions can be prohibitive in even a moderately sized project. Instead, we may use pairwise or t-way testing to provide a guarantee that all pairs or t-way combinations of components are tested(More)
Complete interaction testing of components is too costly in all but the smallest systems. Yet component interactions are likely to cause unexpected faults. Recently, design of experiment techniques have been applied to software testing to guarantee a minimum coverage of all ¢-way interactions across components. However, ¢ is always fixed. This paper(More)
A program was undertaken to identify hit compounds against NADH:ubiquinone oxidoreductase (PfNDH2), a dehydrogenase of the mitochondrial electron transport chain of the malaria parasite Plasmodium falciparum. PfNDH2 has only one known inhibitor, hydroxy-2-dodecyl-4-(1H)-quinolone (HDQ), and this was used along with a range of chemoinformatics methods in the(More)
Computing techniques are described which have resulted in the establishment of new results for the queens domination problem. In particular it is shown that the minimum cardinalities of independent sets of dominating queens for chessboards of size 14, 15, and 16 are 8, 9, and 9 respectively, and that the minimum cardinalities of sets of dominating queens(More)
Following a program undertaken to identify hit compounds against NADH:ubiquinone oxidoreductase (PfNDH2), a novel enzyme target within the malaria parasite Plasmodium falciparum, hit to lead optimization led to identification of CK-2-68, a molecule suitable for further development. In order to reduce ClogP and improve solubility of CK-2-68 incorporation of(More)