We used [18F]cyclofoxy (CF), a potent opiate antagonist with affinity for mu and kappa receptors, and the Scanditronix PC1024-7B PET scanner to study 14 patients with complex partial seizures (CPS), and 14 normal controls. Epileptic foci were localized by prolonged EEG-video monitoring. EEG was recorded continuously during each scan. Immediately before CF… (More)
m-Chlorophenylpiperazine (mCPP) is a mixed serotonin agonist/antagonist used extensively in psychiatric research. Alcoholics show blunted neuroendocrine responses to mCPP, and in some settings mCPP can induce craving for alcohol, particularly among early onset alcoholics. We used 2-[18F]-2-deoxy-D-glucose positron emission tomography to examine the effects… (More)
Urokinase plasminogen activator (UK-PA) is a serine protease impli cated in cancer invasion and metastasis. In this investigation, patients with breast cancers containing high levels of UK-PA antigen had signif icantly higher risk of early disease recurrence and shorter overall survival than did patients with low levels of the protein. In univariate… (More)
The material covered in this thesis falls mainly in two parts. In the first part, which is found in chapter II, the foundations of source coding are considered. A careful introduction to the notion of codes for symbols, blocks and infinite sequences is given. The classical notion of a stationary ergodic source is then introduced as a natural concept arising… (More)
This paper is submitted as a 'fagprojekt' in conjunction with the seminar course entitled 'Semi-nar in Information Theory and its Applications' hosted by Flemming Topsøe at the Institute for Mathematical Sciences at University of Copenhagen in the fall of 2000. The paper is not related to any specific presentation made during the seminar, but rather is the… (More)
In order to investigate a possible interaction between cimetidine and carbamazepine (CBZ) 7 otherwise healthy epileptic patients on a long-term monotherapy with CBZ were given cimetidine (1 g daily) for 7 days. No significant alterations in steady-state plasma concentration of CBZ and the 10,11-epoxide metabolite (CBZ-E) were demonstrated.
The neurophysiologic and neuropsychologic effects and their relation to the kinetics of diazepam (DZ) were studied in 10 patients with impaired liver function of various degrees and in three normal subjects after 10 mg DZ i.v. The plasma concentration data were treated according to a two-compartment open model. Neurophysiologic effect measurements were… (More)
The single dose kinetics of imipramine (IP), nortriptyline (NT), and antipyrine (AP) were compared in 7 healthy subjects. Test doses of AP were given intravenously and test doses of IP and NT were given both orally and by intravenous infusion. The plasma concentration/time curves after intravenous IP and NT were analysed according to a 2-compartment open… (More)