Peter A Nicholl

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To determine whether density and properties of myocardial voltage-sensitive calcium channels may change in the hearts of aged animals, we have compared specific binding of [3H]-nitrendipine ([3H]-NTP) to 1,4-dihydropyridine (DHP) receptors in ventricular homogenate and membrane fractions prepared from the hearts of adult hamsters of different ages. In crude(More)
Whether the density of sarcoplasmic reticulum (SR) calcium release channels/ryanodine receptors in the heart declines with age is not clear. We investigated age-related changes in the density of [3H]-ryanodine receptors in crude ventricular homogenates, which contained all ligand binding sites in heart and in isolated junctional SR membranes. Experiments(More)
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