Peter A Milligan

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AIM If appropriately accounted for in a pharmacokinetic (PK)-pharmacodynamic (PD) model, time-varying covariates can provide additional information to that obtained from time-constant covariates. The aim was to present and apply two models applicable to time-varying covariates that capture such additional information. METHODS The first model estimates(More)
We conducted a multicenter study of the safety, tolerability, and plasma pharmacokinetics of the parenteral formulation of voriconazole in immunocompromised pediatric patients (2 to 11 years old). Single doses of 3 or 4 mg/kg of body weight were administered to six and five children, respectively. In the multiple-dose study, 28 patients received loading(More)
PURPOSE The main purpose of this study was to describe the nature of the relationship between hamstring muscle activity and anterior knee laxity. METHODS This was a cross-sectional study. Anterior knee laxity was measured at 133N and manual maximal forces using the KT2000 knee arthrometer, in 8 ACL-injured and 13 uninjured individuals. Electromyographic(More)
Study Protocol Title A user centred critical care discharge information pack (UCCDIP) for adult critical care patients and their families at the point of discharge from critical care to the ward; a pilot study evaluating feasibility and effectiveness. Summary This study will explore the effectiveness of a user centred critical care discharge information(More)
Previous studies have shown that community-pharmacy– based screening and brief intervention (SBI) for risky alcohol use is feasible. However, few studies have reported significant reductions in alcohol use following pharmacy-delivered BI. In this study, trained pharmacists (N = 29) at 28 community pharmacies in London, UK, offered BI from February-July(More)
Brief intervention (BI) delivered in pharmacies is not currently routine practice, nor is there evidence regarding its efficacy. Community pharmacies attract a large and diverse range of people to a health-care environment that is promising for BI research. Work undertaken by this research group included semi-structured interviews with pharmacy service(More)
OBJECTIVE The aim of the present study was to explore knowledge of the UK weaning guidelines and the sources of weaning advice used by UK first-time mothers. DESIGN An online survey of UK parents; analysed using mixed methods. SETTING Participants were recruited from a selection of parenting websites that hosted a link to the survey. SUBJECTS In(More)
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