Petar Petrov

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Disclaimer This report provides an overview about the research on Digital Preservation of initiatives co-funded by the European Commission in the ICT programme. A subject as complex as the topic research can be seen from many points of view. In order to open new perspectives, we tried to give structured summaries of the activities from different angles. The(More)
Paclitaxel is an antineoplastic drug used against a variety of tumors, but its low aqueous solubility and active removal caused by P-glycoprotein in the intestinal cells hinder its oral administration. In our study, new type of stabilized Pluronic micelles were developed and evaluated as carriers for paclitaxel delivery via oral or intravenous route. The(More)
Deficiency in the retinoblastoma protein (Rb) favors leanness and a healthy metabolic profile in mice largely attributed to activation of oxidative metabolism in white and brown adipose tissues. Less is known about Rb modulation of skeletal muscle metabolism. This was studied here by transiently knocking down Rb expression in differentiated C2C12 myotubes(More)
The aim of the present study was to develop curcumin loaded cationic polymeric micelles and to evaluate their loading, preservation of curcumin antioxidant activity and intracellular uptake ability. The micelles were prepared from a triblock copolymer consisting of poly(ϵ-caprolactone) and very short poly(2-(dimethylamino) ethyl methacrylate) segments(More)
Retinoblastoma (Rb1) has been described as an essential player in white adipocyte differentiation in mice. No studies have been reported thus far in human adipose tissue or human adipocytes. We aimed to investigate the possible role and regulation of RB1 in adipose tissue in obesity using human samples and animal and cell models. Adipose RB1 (mRNA, protein,(More)
Retinoblastoma protein (pRb) is involved in the control of energy metabolism, and its inactivation protects mice against high-fat diet-induced diabesity. Here, we tested the hypothesis that partial deficiency in the Rb gene could confer metabolic advantages in front of acute challenges to metabolism and as mice age on a regular diet. Rb haploinsufficient(More)
Successful preservation of content requires sophisticated mechanisms for collecting, tracking and analyzing information about a multitude of relevant aspects. This is not limited to content itself, but also tracking of available software, other organization’s content, usage statistics and trends, format risks, systems operations and many more. Such tracking(More)
For successful preservation operations, a preservation system needs to be capable of monitoring compliance of preservation operations to specifications, alignment of these operations with the organisation’s preservation objectives, and associated risks and opportunities. This requires linking a number of diverse information sources and specifying complex(More)