Petal A H M Wijnen

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INTRODUCTION Adalimumab, a humanized monoclonal antibody targeted against TNF-α, has proved to be successful in the treatment of uveitis. Another anti-TNF-α agent, i.e., infliximab, has been reported of benefit in the treatment of refractory sarcoidosis. The aim of this prospective case series was to evaluate the effect of adalimumab on intraocular(More)
BACKGROUND Drug-induced pulmonary toxicity is a serious and expanding problem with often unknown aetiology. Many drugs are metabolized by cytochrome P450 (CYP) enzymes. OBJECTIVE To establish whether allelic variation in CYP polymorphic genes contributes to variability in drug response and unexpected toxicity. METHODS A case-control study was conducted.(More)
Responsiveness to tumour necrosis factor (TNF) inhibitors has been associated with the TNF-α G-308A polymorphism in rheumatoid arthritis. The aim of this study was to examine the association between the presence of this polymorphism and the response to TNF inhibitors in patients with refractory sarcoidosis. Patients (n=111) who started TNF-inhibitor(More)
Current methods for PCR use purified genomic DNA, isolated mostly from leukocytes. To avoid time-consuming , and therefore expensive, procedures to purify genomic DNA, methods have been developed that use whole blood or buffy coats for PCR (1–5). However, extensive washing procedures become necessary to remove hemoglobin and anticoagulants, which inhibit(More)
Effect of high flow oxygen on mortality in chronic obstructive pulmonary disease patients in prehospital setting: randomised controlled trial. BMJ 2010; 341: c5462. 4 O'Driscoll BR, Beasley R. Avoidance of high concentration oxygen in chronic obstructive pulmonary disease. BMJ 2010; 341: c5549. 5 Rønning OM, Guldvog B. Should stroke victims routinely(More)
BACKGROUND (18)F-FDG PET/CT (PET) is useful in assessing inflammatory activity in sarcoidosis. However, no appropriate indications are available. The aim of this study was to develop a prediction rule that can be used to identify symptomatic sarcoidosis patients who have a high probability of PET-positivity. METHODS We retrospectively analyzed a cohort of(More)
BACKGROUND Fibrosing interstitial pneumonias (IPs) include idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP). It has been suggested that oxidative damage plays a role in the pathophysiology of idiopathic interstitial pneumonias. Diffuse alveolar hemorrhage (DAH) can cause oxidative stress. Accordingly, we hypothesized that(More)
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