Perumal Subramanian

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Effects of S-allylcysteine (SAC), an organosulfur compound of garlic, on circulatory lipid peroxidation and antioxidant levels were evaluated in N-nitrosodiethylamine (NEDA)-induced hepatocarcinogenesis in Wistar rats. Significantly elevated thiobarbituric acid reactive substances in the circulation of rats bearing carcinoma indicated the higher levels of(More)
Search for new substances with antiproliferative activity and apoptosis inducing potential towards HepG2 cells is important since HCC is notoriously resistant to conventional chemotherapy. Dietary phytochemicals with significant anti-proliferative and apoptosis inducing potential are considered as agents promising for cancer therapy. Naringenin, a common(More)
This study examines the effect of a daily administration of melatonin for 45 days at two doses (0.5 and 1.0 mg/kg body wt.) on antioxidant status, lipid peroxidation and lipid profile in the brain and liver in rats. Both doses of melatonin caused a significant decrease in lipid peroxidation and the levels of cholesterol, phospholipids, triglycerides and(More)
INTRODUCTION Oral cancer is one of the leading cancers in India accounting for 30 to 40 percent of all cancers. Disturbances in lipid peroxidation and antioxidants status have been implicated in the pathogenesis of several cancers including oral cancer. However, circadian disturbances of oxidants and antioxidants in oral cancer patients were not reported.(More)
The present study was aimed to investigate the antioxidant potential of Momordica charantia fruit extract (MCE) in ammonium chloride-induced (AC) hyperammonemic rats. Experimental hyperammonemia was induced in adult male Wistar rats (180-200 g) by intraperitoneal injections of ammonium chloride (100 mg kg(-1) body weight) thrice a week. The effect of oral(More)
Endometrial carcinoma is a malignant tumor of the female genital tract. This study has been performed to evaluate the chemopreventive efficacy of vanillic acid (a bio flavonoid) on endometrial carcinoma (EC) by assessing the levels of thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides (LOOH), cytochrome P450, antioxidants-superoxide(More)
To compare the effects of alpha-ketoglutarate (alpha-KG) and melatonin on 24-h rhythmicity of oxidative stress in N-nitrosodiethylamine (NDEA)-injected Wistar male rats, melatonin (5 mg/kg i.p.) or alpha-KG (2 g/kg through an intragastric tube) was given daily for 20 weeks. In blood collected at 6 time points during a 24-h period, serum activity of(More)
In the present study, we investigated the protective effect of Withania somnifera, an indigenous medicinal herb used in ayurvedic traditional systems for more than 3000 years in India, on gentamicin (GEN)-induced nephrotoxicity. The root extract of three different doses of W. somnifera (viz., 250, 500, and 750 mg/kg) was administered orally to rats for 14(More)
The effect of Pongamia pinnata (an indigenous plant used in Ayurvedic Medicine in India) leaf extract (PPEt) on circulatory lipid peroxidation and antioxidant status was evaluated in ammonium chloride-induced hyperammonemic rats. Enhanced lipid peroxidation in the circulation of ammonium chloride-treated rats was accompanied by a significant decrease in the(More)
Chronic ingestion of ethanol for 60 days was known to alter the characteristics of biochemical circadian rhythms in Wistar rats. Peak times of glucose, potassium and lactic acid rhythms were delayed by 18 h, 3 h, and 3 h respectively, whereas peak times of cholesterol and malondialdehyde rhythms were advanced by 3 h and 9 h respectively during ethanol(More)