Perrin M Wilson

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Glial-guided neuronal migration is a key step in the development of laminar architecture of cortical regions of the mammalian brain. We previously reported that neuronal protein astrotactin (ASTN1) functions as a neuron-glial ligand during CNS glial-guided migration. Here, we identify a new Astn family member, Astn2, that is expressed at high levels in(More)
PURPOSE Vitamin A-deficient humans and animals are more susceptible to infections than are healthy humans and animals. This study compares the early corneal response (within 24 hours) to an experimental Pseudomonas aeruginosa infection between vitamin A deficient and control rats. METHODS Male WAG/Rij/MCW rats were fed either a vitamin A- deficient diet(More)
Various functions involving the central nervous system can be manipulated by the sequential administration of p-chlorophenylalanine and 5-hydroxytryptophan, compounds which respectively inhibit and restore the synthesis of 5-hydroxytryptamine in the brain. An involvement of 5-hydroxytryptamine in the control of a particular function has been considered(More)
Activities of daily living scales can be a useful tool in assessing change in people with dementia, either as the disease progresses or in response to treatment. However, little data exist as to the sensitivity to change of instruments used. The Bristol Activities of Daily Living Scale was developed with assistance from the carers of community dwelling(More)
PURPOSE To determine if the cornea synthesizes alpha 1-proteinase inhibitor (alpha 1-antitrypsin). METHODS Human corneas were placed in organ culture for 24 hours in the presence of 35S-methionine to radiolabel corneal proteins. Monoclonal antibodies were used to precipitate labeled alpha 1-proteinase inhibitor. The immunologically isolated inhibitor was(More)
The times of origin of neurons in the septum, amygdala and hippocampus of the marsupial brushtailed possum, Trichosurus vulpecula, were determined with 3H thymidine autoradiography. The long time period for neurogenesis in the brushtailed possum facilitated analysis of neurogenetic gradients in the brain. A series of 20 possums were injected with 3H(More)
Objectives: The purpose of this study was to examine the effects of different scoring protocols used with instruments designed to assess motivation in line with Organismic Integration Theory (OIT; Deci & Ryan, 2002). Design: This study used non-probability based sampling within a cross-sectional (survey) design. Methods: Participants across four samples(More)
The dorsal tegmental pathway in the rat brain has been studied using acetylcholinesterase (AChe) staining alone, after lesions, and combined with the horseradish-peroxidase (HRP) tracing method. This paper characterises in photographs, diagrams and text the origins, form, extent and relations of its visible AChe-staining fibres in 3 planes. This record(More)
PURPOSE The purposes of this study were to determine whether the proteinase inhibitor alpha 2-macroglobulin is present in the cornea, and, if so, where it is located, and whether it is synthesized by the cornea, and, if so, where it is being synthesized. METHODS alpha 2-Macroglobulin was immunolocalized using a double antibody technique and quantified by(More)
A retrospective study of the clinical features in 39 children who were investigated for evidence of Coxsackie B virus (CBV) infection is reported. Eighteen children were found to have serological evidence of infection. An extensive range of features was elicited in both seropositive and seronegative patients, most children complaining of abnormalities(More)