Pernelle Noize

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Metastatic colorectal cancer (mCRC) is frequent among elderly patients. However, in the era of new targeted therapies, little is known about real-life mCRC treatment in this population. This study aimed to describe elderly mCRC patients and the current real-life treatment practices. mCRC patients aged ≥65 years were identified using the registry of(More)
PURPOSE Precise determination of drug exposure is fundamental in pharmacoepidemiology. Drug exposure is often presumed from health insurance claims but this may not correspond exactly to what subjects actually take. This study was designed to investigate French reimbursement databases in assessing drug use. METHODS Between 1999 and 2001, 9294 subjects(More)
BACKGROUND Since its introduction in France, ketoprofen for topical use has been associated with a large number of cutaneous adverse effect reports. Therefore, the French Medicine Agency progressively introduced warnings and contraindications to its use. Despite this, serious adverse drug reactions (ADRs) still occur. OBJECTIVE To describe clinical(More)
To assess the incidence of hospital admissions related to adverse drug reactions (ADRs) in France and the frequency of preventable ADRs in France, a prospective study was conducted among a representative randomly selected sample of medical wards in public hospitals between December 2006 and June 2007; all patients admitted during a 2-week period were(More)
OBJECTIVE The prevalence of benzodiazepine use among community-dwelling older persons varies between 10% and 30%. The aim of this study was to explore the association between leisure activities and the use of benzodiazepine among older persons living at home. METHODS The study population included 4848 persons aged 65 years and over living in either of two(More)
OBJECTIVE To evaluate the validity of chronic drug exposure presumed from cross-sectional interviews taking reimbursement data as reference. STUDY DESIGN AND SETTING The study concerned 2,985 elderly persons of the French Three-City cohort (1) who were interviewed on current drug use 2 and 4 years after inclusion and (2) whose reimbursement data were(More)
PURPOSE To study trends in incident use of benzodiazepines in France between 2006 and 2012. METHODS A cross-sectional study repeated yearly was conducted using data from the French national healthcare insurance system. New benzodiazepine users were defined as users without any benzodiazepine dispensing in the year prior to the first dispensing of(More)
Treatment of metastatic colorectal cancer (mCRC) has been modified since the launching of targeted therapies. Colorectal cancer (CRC) is common in elderly patients; their representation in randomized controlled trials (RCTs) is thus crucial. This study aimed to evaluate and quantify the inclusion of elderly/frail patients in RCTs of targeted therapies in(More)
PURPOSE To describe the use of psychotropic drugs in children aged 0-5 years, in the Aquitaine region of South-west France and identify associated socio-demographic, familial and medical factors. METHODS Data used in this study come from the regional drug claims database of the National Health Insurance System of Aquitaine and from postal(More)
OBJECTIVE To quantify and characterize the use of the Internet to search for information about medicines. METHODS A random sample of subjects was interviewed in the city of Bordeaux (France) in November 2012 regarding their use of the Internet to find information on medicines. RESULTS Among 103 interviewed subjects (median age: 38 years; 53.4% of men),(More)