Per H. Andersen

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The focus of this paper is the implementation and utilization of an inexpensive heterogeneous multicomputer cluster for the study of load balancing techniques. The basic conclusion of the paper is that excellent performance is possible provided that the proper choices among various parameters and implementation options of the load balancing schemes
A general methodology based on software engineering principles is proposed for the parallelization of existing sequential code. The utility of the proposed methodology is evaluated through a case study involving a numerically intensive application in the domain of petrochemical exploration. The methodology does not assume the existence of detail design(More)
INTRODUCTION The point mutation of 3243A>G mtDNA is the most frequent cause of mitochondrial diabetes, often presenting as the syndrome maternally inherited diabetes and deafness (MIDD). The mutation may also cause myopathy, ataxia, strokes, ophthalmoplegia, epilepsy, and cardiomyopathy in various combinations. Consequently, it is difficult to predict the(More)
Multiple endocrine neoplasia type 1 (MEN1) is caused by autosomal dominantly inherited mutations in the MEN1 gene. Here, we report 25 MEN1 mutations - of which 12 are novel - found in 36 Danish families with MEN1 or variant MEN1 disease. Furthermore, one FIHP family was found to have an earlier reported mutation. The mutations were predominantly found in(More)
BACKGROUND/AIMS The insulin-dependent glucose transporter GLUT4 mediates 50-80% of whole body glucose uptake, but its relation to the frequent glucose intolerance in patients with liver cirrhosis is unknown. METHODS Thirty patients and seven healthy controls underwent a 2-h oral glucose tolerance test and later a muscle biopsy. Levels of GLUT4 total(More)
Mitochondrial dysfunction is associated with several clinical manifestations including diabetes mellitus (DM), neurological disorders, renal and hepatic diseases, and myopathy. Although mitochondrial dysfunction is associated with increased bone resorption and decreased bone formation in mouse models, effects of alterations in mitochondrial function on bone(More)
ii ACKNOWLEDGMENTS I am very grateful to my advisor Dr. Michael Shin for suggesting this wonderful topic to me and giving me appropriate guidance and freedom during my work. This thesis could not have been completed without his continued support, patience, and trust that kept me focused. I would to thank my friends and colleagues whose critical feedback and(More)
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