Per E. Andersson

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A parallel nanoliter microfluidic analysis system based on capillary action, centrifugal force, and hydrophobic barriers is described. The precision of 112 parallel volume definition operations is determined to 0.75% CV at 200 nL using the individual sample introduction structure. For 20 nL, the actual measurement error is the dominating factor, with a(More)
A model which takes into account both stray light and polychromatic light was used to predict and evaluate linearity in on-capillary detection in capillary electrophoresis (CE). According to the model the stray light is the major factor which determines linearity under typical CE operating conditions. By calculating theoretical absorbance versus(More)
A new precolumn reagent for amino acid determination, 2-(9-anthryl)ethyl chloroformate (AEOC), was introduced to obtain higher sensitivity in two capillary separation techniques, liquid chromatography (LC) and electrophoresis (CE). The chromophore in the (9-fluorenyl)methyl chloroformate (FMOC) reagent was replaced by anthracene, which resulted in a reagent(More)
BACKGROUND We explored the potential of a microfluidic device based on centrifugal force as an immunoassay platform by examining the imprecision of assays carried out with 200 nL of sample. METHODS Biotinylated antibodies against alpha-fetoprotein (AFP), interleukin-6 (IL-6), and carcinoembryonic antigen [(CEA); 0.1 g/L each in 15 mmol/L(More)
Radio frequency ablation (RFA) is a commonly used minimally invasive method of treating liver cancer tumours which utilises RF current for heating tumour tissue up to a lethal temperature. RF current is generated by a power generator and applied to the tumour by an electrode which is inserted into the tumour either during percutaneous or open surgery. RFA(More)
Potentiometric end-capillary detection in capillary electrophoresis has the advantage of relatively easy miniaturisation without having to compromise the concentration sensitivity. Potentiometric end-capillary detection using a copper electrode is also attractive because of the sensitive detection of many inorganic and organic UV-transparent ions and the(More)
The iterative regression design developed earlier for high performance liquid chromatography (HPLC) has been applied successfully to the optimization of the separation of 11 metal ions by capillary electrophoresis. The parameters used for optimization were pH (over the range 3.5-5.0) and the concentration of 2-hydroxyisobutyric acid (HIBA) (2-20 mM) used as(More)
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