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STUDY OBJECTIVE To evaluate the clinical and biochemical features of patients with TSH (thyroid-stimulating hormone, thyrotropin)-secreting pituitary tumors; to measure the biologic activity in vitro of circulating TSH from selected patients before and after pituitary surgery. DESIGN Case series. SETTING Patients in an endocrinology unit. PATIENTS(More)
The role of stressful life events in the onset of Graves' disease (toxic diffuse goitre) is controversial. However, the numerous early clinical reports that supported such an association were not adequately controlled and specificity of the diagnosis could be questioned. Later studies have not shown a causal relation, but these studies were small, did not(More)
The objective of this paper is to discuss how to enable the staff at an order-packaging department to cope with a drastically increasing scale of operation. In order to do this we introduce the term scalability and based on coordination theory we formulate a case specific method for designing for an increasing scale of operation. We argue that it is the(More)
The outcome of a standardized carbimazole (CMI) regimen was evaluated in fifty-four patients with Graves' disease. Triiodothyronine (T3) and thyroxine (T4) serum values were determined before and throughout the first 6-8 months of therapy. Before therapy, decreasing T4/T3 ratios were found with increasing T3 levels, reflecting a relative increase in T3(More)
In this study we investigated the oral bioavailability of therapeutic doses of two antithyroid drugs, methimazole and carbimazole, in seven euthyroid subjects. To increase the statistical power deuterium-labeled methimazole was given orally as an internal standard together with the tested drugs. Using a recently described highly sensitive gas(More)
Among 78 consecutive patients with Graves' disease, an increased frequency of HLA-B8 and HLA-DR3 antigens was found. The relative risk for Graves' disease among individuals with these HLA antigens was calculated as 4.4 and 3.9, respectively. Thus, genes promoting the development of Graves' disease are clearly associated to the B8 and DR3 haplotypes. In(More)
In a longitudinal study carried out for 2 yr in the Darfur region, western Sudan, 2316 school children received a single dose of 2 capsules of iodized oil (400 mg iodine) orally, and 1161 school children received 1 ml of the same preparation im (475 mg iodine); 2393 school children served as controls. One year after treatment, goiter prevalence was reduced(More)
BACKGROUND In Sweden, native and transplant kidney biopsies are usually performed in major renal medical centers. PURPOSE To clarify risk factors in native and transplant kidney biopsies to improve patient safety. MATERIAL AND METHODS A total of 1001 biopsies (in 352 women and 565 men) were included. The median age was 54 years (range, 16-90 years).(More)