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The role of stressful life events in the onset of Graves' disease (toxic diffuse goitre) is controversial. However, the numerous early clinical reports that supported such an association were not adequately controlled and specificity of the diagnosis could be questioned. Later studies have not shown a causal relation, but these studies were small, did not(More)
" The structuring properties of the interaction order in real-time settings such as meetings have enormous (and as yet largely ignored) consequences for the overall structuring of organizations. Caught in a meeting and connected through a series of interactions across time and space are the people, ideas, decisions, and outcomes that make the organization.(More)
The objective of this paper is to discuss how to enable the staff at an order-packaging department to cope with a drastically increasing scale of operation. In order to do this we introduce the term scalability and based on coordination theory we formulate a case specific method for designing for an increasing scale of operation. We argue that it is the(More)
The keeping quality of milk can be improved if the lactoperoxidase system is activated. To make such an activation efficient the thiocyanate concentration has to be increased. Since, however, thiocyanate has a potent antithyroid effect, thyroid function has been studied in 37 healthy individuals during 12 wk of daily intake of 8 mg thiocyanate by way of(More)
Among 78 consecutive patients with Graves' disease, an increased frequency of HLA-B8 and HLA-DR3 antigens was found. The relative risk for Graves' disease among individuals with these HLA antigens was calculated as 4.4 and 3.9, respectively. Thus, genes promoting the development of Graves' disease are clearly associated to the B8 and DR3 haplotypes. In(More)
A sensitive gas chromatographic-mass spectrometric method enabled us to study intrathyroidal concentrations of methimazole in 20 euthyroid patients with Graves' disease on treatment with carbimazole and T4. There was no difference between patients receiving a final dose of carbimazole (10 mg), known to be totally bioactivated to methimazole (6.1 mg), 3-6 h(More)
A sensitive in vitro assay based on the uptake of 125I by the FRTL-5 rat thyroid cell line has been applied to the measurement of TSH bioactivity from different sources. In this bioassay various human pituitary reference preparations showed similar potencies; the limit of detection and the half-maximal response were 1.60 +/- 0.1 (+/- SE) and 9.70 +/- 0.40(More)