Per-Anders Hellström

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BACKGROUND Several components of the metabolic syndrome coincide with those risk factors linked to sensorineural hearing loss (SNHL). According to the thrifty phenotype hypothesis, the metabolic syndrome can be caused by events during the fetal period. This study tests the thrifty phenotype hypothesis on hearing, using body size at birth and conscription as(More)
It has been established that the human gut microbiome is commensal, helps to digest our food, and is involved in metabolic processes in the gut and in the development and maintenance of our immune systems.[1] The microbiome and its genes process the primarily indigested food we eat and deliver metabolites, which frequently are taken up in our blood and by(More)
In a retrospective study of 39 splenectomies, patients with increased blood cell breakdown (13 cases of idiopathic thrombocytopenic purpura (ITP), 5 cases of hereditary spherocytosis, 2 of Felty's syndrome and 2 of autoimmune hemolytic anemia) were compared with those patients also presenting decreased blood cell production [14 cases of myelofibrosis (MF)(More)
Prokinetic drugs--preparations that stimulate gastro-intestinal motility--constitute a relatively new concept in medical therapy, chiefly represented by the products cisapride and metoclopramide. This review consists in an account of the physiological regulation of motility in the upper gastro-intestinal tract where prokinetic drugs are considered to exert(More)
This review explores the definition, assessment and possible restoration of impaired insight in psychosis. Hypotheses concerning the neuropsychological correlates of insight impairment are discussed. The distinction between impaired insight in psychosis and impaired awareness and psychological denial in other medical conditions is emphasised.
This review examines the neurobiological underpinnings of impaired insight and awareness in psychosis. Crucial mainly dopaminergic pathways are discussed in relation to delusions and hallucinations. Thirty percent of psychotic patients with impaired insight will not respond to traditional neuroleptic drug treatment, and the possibility that multifocal brain(More)
BACKGROUND We previously found that DNA synthesis of the colonic mucosa rises under protracted physical stress. At 8 stress weeks DNA values regained those of untreated animals, and was regarded as DNA adaptation to stress. AIMS To assess whether the 8 weeks' DNA adaptation to stress could be maintained following stress-free intervals, ending with a(More)
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