Pentti Kotilainen

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Despite much interest in the effects of exercise on the myocardium, and the need to develop animal models which mimic conditions leading to cardiac hypertrophy, little attention has been focused on the trained racing greyhound. The current study compared two groups of anesthetized trained racing greyhounds (a total of 20 animals, 12 of whom were maintained(More)
Despite decreasing heart rate, left ventricular ejection time (LVET) transiently falls immediately following bicycle exercise. In seven normal, untrained subjects LVET decreases at 15 s postexercise corresponded (r = 0.78) with an increase in transthoracic electrical impedance (Z) consistent with decreased venous return to the thorax. Because the(More)
Continuous ambulatory electrocardiographic monitoring of ST-segment configuration has become a useful technique for evaluation of myocardial ischemia. Concern that direct or amplitude-modulated (AM) recording and playback systems have inherent limitations that cause inaccurate ST-segment recordings has led to preference for frequency-modulated (FM) devices.(More)
Exercise responses depend on work load and its pattern of delivery. Administering a very brief ("impulse") load aims to elicit significant responses through biologic sensitivity to rate - rather than degree - of change. Electrocardiograms, systolic time intervals (STI) and heart rate (HR) were recorded continuously in 10 normal subjects during and after(More)
In 12 normal subjects, use of ear densitography permitted measurement of systolic time intervals (STI) during uninterrupted treadmill exercise to over 90 percent maximal heart rate on a modified Bruce protocol. Results for control (sitting leads to standing) leads to end-exercise at 18 minutes leads to 10 minutes' sitting recovery were--heart rate (HR): (77(More)
Adding physiologic data to ambulatory electrocardiographic monitoring data yields information with great potential for diagnostic and therapeutic use. The ear densitogram's stability, demonstrated during exercise and under laboratory conditions, indicates its applicability to ambulatory monitoring as a source of systolic time intervals. Circuitry has been(More)
We present a patient who had progressive paraparesis. Left lateromedial disc herniation was diagnosed at T10 to T11 level on MR imaging. This was operated on, but 3 months later paraparesis worsened and then a suspicion of spinal vascular malformation arose. Spinal angiogram showed dural arteriovenous fistula at T11 level on the right side. This was(More)
Manufacturers are challenged with providing ST-segment monitoring devices in a timely manner that meet the needs of clinicians and that satisfy the purview of the Federal Drug Administration (FDA) Office of Device Evaluation. The initial challenge is to explain the intended use for the product; are clinicians using the monitoring device to view measured(More)
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