Penny Wilton

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BACKGROUND We have previously shown that a specific combination of drug therapy and left ventricular assist device unloading results in significant myocardial recovery, sufficient to allow pump removal, in two thirds of patients with dilated cardiomyopathy receiving a Heartmate I pulsatile device. However, this protocol has not been used with nonpulsatile(More)
Sprague-Dawley rats were nephrectomized unilaterally, or sham-operated at 5, 12, and 40 days of age. The kidney weight, number of glomeruli, GFR, and single nephron GFR (SNGFR) were determined in about 60 days of age. In both sham-operated and nephrectomized rats operated on at 5 and 12 days of age, the kidney was studied with light microscope for 1 to 14(More)
To evaluate the interpretation of different kidney function tests in diabetic children and teenagers we have studied 47 children with a duration of diabetes up to 5 years, 61 children with a duration of 5.1-10 years and 49 children with a duration of greater than 10 years. Glomerular filtration rate (GFR) measured as inulin clearance or creatinine(More)
The renal response to volume expansion was determined in four patients with renal hypertrophy due to unilateral renal agenesis (URA) and in four patients with renal hypertrophy due to nephrectomy (Nz). Four healthy controls were also studied. The studies were performed during water diuresis and following i.v. infusion of isotonic saline solution.(More)
Eight patients nephrectomized in childhood were studied with regard to growth and function of the remaining kidney. The age of the patients ranged between 8 1/2 and 31 years and the follow-up period was from 1 to 20 years. In most of the patients, repeated renal size determinations were made on postoperative urograms. Normal values for kidney size in(More)
Kidney parenchymal size was estimated on urograms from 22 children with unilateral vesico-ureteral reflux (VUR), 14 children with bilateral VUR and seven children with unilateral heminephrectomy. In the bilateral VUR group, one kidney was roentgenologically normal and the other was growth-retarded. The GFR was estimated in 19 of the children. The age of the(More)
OBJECTIVES Left ventricular assist device (LVAD) implantation may alter right ventricular shape and function and lead to tricuspid regurgitation. This in turn has been reported to be a determinant of right ventricular (RV) failure after LVAD implantation, but the effect of mechanical left ventricular (LV) unloading on the tricuspid annulus is unknown. The(More)
Most girls with Turner's syndrome seemed to increase their growth rate during the first year of growth hormone treatment. The gain is rarely more than 3 cm/year. In 3 studies the combination of growth hormone and an anabolic steroid resulted in higher growth rates compared to those with each individual compound. The results of long-term treatment (more than(More)
Systolic and diastolic blood pressure were measured in 1642 Swedish school children aged 12, 14, or 16 years. They represented 71% of all children in these age groups in the municipality where the investigation was done. The blood pressure was measured with an automatic, oscillometric blood pressure monitor. The systolic blood pressure increased(More)
Introduction: Ventricular septal rupture (VSR) is an unusual mechanical complication of myocardial infarction (MI) in the era of reperfusion therapy, but the mortality rate of patients who present with cardiogenic shock (CS) remains extremely high. Whereas current American and European guidelines recommend urgent surgical repair regardless of hemodynamic(More)