Penny McCarthy

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Using a sensitive electrochemical assay for vitamin K1 and standardized techniques for breast-milk collection, we studied the vitamin K1 content of human milk during the first 5 wk of lactation with respect to 1) individual and interindividual differences, 2) the relationship of vitamin K1 to other lipids, and 3) the influence of oral supplements of vitamin(More)
The aim of this study was to determine whether patients' tolerance of upper gastrointestinal endoscopy is related to the dose of lignocaine spray used for oropharyngeal anaesthesia and to measure plasma concentrations at these doses. Sixty consecutive patients undergoing routine upper gastrointestinal endoscopy with sedation were randomized to receive(More)
A simple method for the measurement of clozapine and its N-desmethyl metabolite in human plasma or serum by high performance liquid chromatography is described. An internal standard (aqueous nortriptyline, 4 mg/L) (50 microL) and Tris buffer (2 mol/L, pH 10.6) (100 microL) are added to plasma/serum (200 microL) and the analytes and internal standard(More)
A case is described in which Lipiodol, selectively injected into the hepatic artery as part of the investigation of a patient with hepatocellular carcinoma, was retained at the site of a previous liver biopsy leading to the false positive diagnosis of a daughter nodule. This has not been previously described.
In conclusion, it would appear from present evidence that several statements can be made. First, MRI is the most accurate method of staging the periprostatic spread of carcinoma. Both the prostate and the regional nodes can be evaluated. The role of ultrasound is, at present, unclear. Second, the utility of CT has diminished with the emergence of(More)
1. The concentrations of amiodarone/desethylamiodarone, digoxin, flecainide and sotalol were measured in serum collected immediately prior to death and in postmortem blood collected from the femoral vein and artery of an 18-year-old male with congenital heart disease who developed a fatal arrhythmia. 2. The concentrations of all four drugs in the sample(More)