Penny J Claisse

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Two types of tumour cell have been obtained from a glioma transplacentally induced by ethylnitrosourea in a BD-IX rat. These were distinguished in culture by their different morphologies, responses to dibutyryl cyclic adenosine monophosphate, inducibility of glycerol phosphate dehydrogenase and growth in soft agar. They had different karyotypes, with(More)
This study demonstrates the effect of orthotic therapy for toe deformity on toe and metatarsal head pressures using a new analysis method facilitated by an in-shoe pressure-measurement system's ability to export detailed data. Plantar pressure-time integrals in 11 individuals (22 feet) with claw deformity of the lesser toes were measured with and without(More)
Cultures derived from rat brains at different times during the latent period of brain-tumour induction by N-ethyl-N-nitrosourea (ENU) showed increased plasminogen activator (PA) activity before being able to form colonies in agar. Control cultures from buffer-exposed animals showed neither property at comparable passages. More detailed investigations, using(More)
A SEQUENTIAL in vivo-ini vitr-o model system has been developed for studying carcinogenesis in the rat brain after trans-placental expostire to ethylnitrosotirea Although cultures derived early in the latent period required prolonged passaging before becoming malignant or forming colonies in agar, they exhibited differences in other properties, including(More)
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