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0x1.~ limited success has been obtained in tieveloping strains of h u m a n cells that can be cultivateti for long periods of time in uitro and that still preserve the diploid chromosomal configuration [41, 47, 48, 58, 591. Indeed, heteroploidy may be a necessary corollary or even the cause of the alteration of primary or tliploid cells in uitro to the(More)
It has been previously demonstrated (1) that the length of the period of DNA synthesis (S period) as measured by uptake of tritiated thymidine is approximately the same in several animal cells. Since the length of this period (with a range of 6/~ to 8 hours) appears to be independent of the species of the cell, the chromosome number, the cells of human(More)
Complete automation of the macromolecular crystallography experiment has been achieved at SSRL through the combination of robust mechanized experimental hardware and a flexible control system with an intuitive user interface. These highly reliable systems have enabled crystallography experiments to be carried out from the researchers' home institutions and(More)
Three new tissue culture cell lines, CHP-100, CHP-126, and CHP-134, have been established from explant cultures of human neuroblastoma. The cell lines have been characterized with respect to morphology, chromosomes constitution, growth, neural enzyme content, and their ability to grow in nude mice. The cells grow as dense masses comprised of fibroblast-or(More)