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Rational design of 2-pyrrolinones as inhibitors of HIV-1 integrase.
- Kaiqing Ma, Penghui Wang, +4 authors D. Ye
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 15 November 2011
HIV-1 integrase is an essential enzyme for viral replication and a validated target for the development of drugs against AIDS. With an aim to discover new potent inhibitors of HIV-1 integrase, we… Expand
RNA-binding protein RPS3 contributes to hepatocarcinogenesis by post-transcriptionally up-regulating SIRT1
Abstract Although several studies indicate that RNA-binding proteins (RBPs) contribute to key steps in a variety of physiological processes and cancer, the detailed biological functions and… Expand
Xanthone derivatives as phosphoglycerate mutase 1 inhibitors: Design, synthesis, and biological evaluation.
- Penghui Wang, Lulu Jiang, +6 authors L. Zhou
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 1 May 2018
Phosphoglycerate mutase 1 (PGAM1) is a glycolytic enzyme that dynamically converts 3-phosphoglycerate (3PG) to 2-phosphoglycerate (2PG), which was upregulated to coordinate glycolysis, pentose… Expand
Role of ten‐eleven translocation proteins and 5‐hydroxymethylcytosine in hepatocellular carcinoma
In mammals, methylation of the 5th position of cytosine (5mC) seems to be a major epigenetic modification of DNA. This process can be reversed (resulting in cytosine) with high efficiency by… Expand
An allosteric PGAM1 inhibitor effectively suppresses pancreatic ductal adenocarcinoma
- Chen-Lei Wen, K. Huang, +29 authors L. Zhou
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 29 October 2019
Significance Dysregulated metabolism is one of the hallmarks of pancreatic ductal adenocarcinoma, which is the major subtype of pancreatic cancer considered as the deadliest malignancy worldwide.… Expand
Effect of Nitric Acid Modification on Characteristics and Adsorption Properties of Lignite
The objective of this research was to explore the changes of the pore structure and surface properties of nitric-modified lignite and base the adsorption performance on physical and chemical… Expand
Site-selective phosphoglycerate mutase 1 acetylation by a small molecule.
Post-translational modifications play vital roles in fine tuning a myriad of physiological processes, and one of the most important modifications is acetylation. Here, we report a ligand-directed… Expand
Iron and Iodine Co-doped Triazine-Based Frameworks with Efficient Oxygen Reduction Reaction in Alkaline and Acidic Media
The oxygen reduction reaction (ORR), which is a crucial process in fuel cells and metal-air batteries, is currently dominated by Pt-based electrocatalysts. However, these catalysts are expensive and… Expand
The Design and Synthesis of N-Xanthone Benzenesulfonamides as Novel Phosphoglycerate Mutase 1 (PGAM1) Inhibitors
Upregulation of phosphoglycerate mutase 1 (PGAM1) has been identified as one common phenomenon in a variety of cancers. Inhibition of PGAM1 provides a new promising therapeutic strategy for cancer… Expand
Oncogenic and prognostic role of CKAP2L in hepatocellular carcinoma.
Cytoskeleton-associated protein 2-like (CKAP2L) exerts crucial function in the cell-cycle progression and mitotic spindle formation of neural stem/progenitor cells. However, in hepatocellular… Expand