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Antisense oligonucleotides were utilized to interfere with the synthesis of progesterone receptor. A specific aODN was shown to decrease significantly the levels of PR in the T47D cell line known to express the PR gene. The molecule described was proved to be effective in hindering the effect of progesterone on target gene expression in T47D cells. The aODN(More)
[1] Physical mechanisms for the summertime offshore detachment of the Changjiang Diluted Water (CDW) into the East China Sea are examined using the high-resolution, unstructured-grid, Finite-Volume Coastal Ocean Model (FVCOM). The model results suggest that isolated low salinity water lens detected west of Cheju Island can be formed by (1) a large-scale(More)
—Water plays a vital role in the proper functioning of the Earth's ecosystems, and practically all human activities, such as agriculture, manufacturing, transportation, and energy production. The proliferation of industrial and agricultural activities in modern society, however, poses threats to water resources in the form of chemical, biological, and(More)
[1] Observing system simulation experiments (OSSEs) were performed for Nantucket Sound, Massachusetts, as a pilot study for the design of optimal monitoring networks in the coastal ocean. Experiments were carried out using the ensemble Kalman filter (EnKF) for data assimilation with ensemble transform Kalman filter (EnTKF) and proper orthogonal(More)
[1] The Changjiang River (CR) is divided into a southern branch (SB) and a northern branche (NB) by Chongming Island as the river enters the East China Sea. Observations reveal that during the dry season the saltwater in the inner shelf of the East China Sea flows into the CR through the NB and forms an isolated mass of saltwater in the upstream area of the(More)
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. [1] Twin experiments were made to compare the reduced rank Kalman filter(More)
Protein kinase D2 (PKD2) has been demonstrated to promote tumorigenesis in many types of cancers. However, how PKD2 regulates cancer cell growth is largely unknown. In this study, we found that over-expression of PKD2 promoted glioma cell growth but down-regulation of PKD2 inhibited it. Further investigation indicated that PKD2 down-regulation decreased the(More)
Protein phosphatase 4 catalytic subunit (PP4C) has been identified to be overexpressed in various solid cancers. However, to date, the role of PP4C in glioma remains elusive. In the present study, we aimed to detect PP4C expression in glioma patients and explore its function in glioma and prognostic significance in patients with glioma. The expression(More)
Microstructure, mechanical properties, superelasticity and biocompatibility of a Ti-19Zr-10Nb-1Fe alloy are investigated. X-ray diffraction spectroscopy and transmission electron microscopy observations show that the as-cast Ti-19Zr-10Nb-1Fe alloy is composed of α' and β phases, but only the β phase exists in the as-rolled and as-quenched alloys. The(More)
Climatological high resolution coupled climate model simulations for the maritime continent have been carried out using the regional climate model (Reg-CM) version 3 and the finite volume coastal ocean model (FVCOM) specifically designed to resolve regions characterized by complex geometry and bathymetry. The RegCM3 boundary forcing is provided by the(More)