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Knowledge and investigation of therapeutic targets (responsible for drug efficacy) and the targeted drugs facilitate target and drug discovery and validation. Therapeutic Target Database (TTD, http://bidd.nus.edu.sg/group/ttd/ttd.asp) has been developed to provide comprehensive information about efficacy targets and the corresponding approved, clinical(More)
BACKGROUND Mounting evidence indicates that obesity may be associated with the risk of colorectal cancer (CRC). To conduct a systematic review of prospective studies assessing the association of obesity with the risk of CRC using meta-analysis. METHODOLOGY/PRINCIPAL FINDINGS Relevant studies were identified by a search of MEDLINE and EMBASE databases(More)
A topic propagating in a social network reaches its tipping point if the number of users discussing it in the network exceeds a critical threshold such that a wide cascade on the topic is likely to occur. In this paper, we consider the task of selecting initial seed users of a topic with minimum size so that {\em with a guaranteed probability} the number of(More)
In our in-depth analysis carried out by the Illumina Solexa massive parallel signature sequencing, microRNA-99a (miR-99a) was found to be the sixth abundant microRNA in the miRNome of normal human liver but was markedly down-regulated in hepatocellular carcinoma (HCC). Compelling evidence has suggested the important roles of microRNAs in HCC development.(More)
PURPOSE To conduct a systematic review of prospective studies assessing the association of vitamin D intake or blood levels of 25-hydroxyvitamin D [25(OH)D] with the risk of colorectal cancer using meta-analysis. METHODS Relevant studies were identified by a search of MEDLINE and EMBASE databases before October 2010 with no restrictions. We included(More)
Image quality assessment (IQA) tries to estimate human perception based image visual quality in an objective manner. Existing approaches target this problem with or without reference images. For no-reference image quality assessment, there is no given reference image or any knowledge of the distortion type of the image. Previous approaches measure the image(More)
Robotic colorectal surgery may solve some of the problems inherent to conventional laparoscopic surgery (CLS). We sought to evaluate the advantages of robot-assisted laparoscopic surgery (RALS) using the da Vinci Surgical System over CLS in patients with benign and malignant colorectal diseases. PubMed and Embase databases were searched for relevant studies(More)
In this study, brain activation associated with forward and backward digit recall was examined in healthy old and young adults using functional MRI. A number of areas were activated during the recall. In young adults, greater activation was found in the left prefrontal cortex (BA9) and the left occipital visual cortex during backward digit recall than(More)