Learn More
Diabetic neuropathic pain (DNP) plays a major role in decreased life quality of type 2 diabetes patients, however, the molecular mechanisms underlying DNP remain unclear. Emerging research implicates the participation of spinal glial cells in some neuropathic pain models. However, it remains unknown whether spinal glial cells are activated under type 2(More)
Oxidative injury has been implicated in the etiology of Parkinson's disease (PD). Gypenosides (GPs), the saponins extract derived from the Gynostemma pentaphyllum, has various bioactivities. In this study, GPs was investigated for its neuroprotective effects on the 1-methyl-4-phenylpyridinium ion (MPP(+))-induced oxidative injury of dopaminergic neurons in(More)
The relation between a firm's stock return and its intangible assets is derived under the intangible-asset-augmented q-theory framework. The structural estimation of the model leads to four main results. First, the q-theory augmented with intangible investments captures the value premium and the relation between R&D intensity and stock returns significantly(More)
Small ubiquitin-related protein modifiers (SUMO) modification is an important mechanism for posttranslational regulation of protein function. However, it is largely unknown how the sumoylation pathway is regulated. Here, we report that nitric oxide (NO) causes global hyposumoylation in mammalian cells. Both SUMO E2 conjugating enzyme Ubc9 and E3 ligase(More)
Alomair proposed a new authenticated encryption scheme OKH at ACNS 2012, and proved the security, i.e. authenticity and privacy , of OKH. Our research shows that it is not the case. We only need one query to break the authenticity of OKH with success probability of 1, and two queries to break the privacy of OKH with success probability of 1 − 1/2 n , where(More)
Among various cryptographic schemes, CBC-based MACs belong to the few ones most widely used in practice. Such MACs iterate a blockcipher EK in the so called Cipher-Block-Chaining way, i.e. Ci = EK (Mi ⊕ Ci−1) , offering high efficiency in practical applications. In the paper, we propose a new deterministic variant of CBC-based MACs that is provably secure(More)
OBJECTIVE To study the long-term effects of deep brain stimulation (DBS) of the bilateral subthalamic nucleus (STN) on depression in patients with Parkinson's disease (PD) and to discuss the mechanism. METHODS A STN-DBS group (n = 27) and anti-Parkinson's medication control group with paired designing were set up. The evaluation of the depression and(More)
Chemotherapy-induced neuropathic pain (CNP) is the major dose-limiting factor in cancer chemotherapy. However, the neural mechanisms underlying CNP remain enigmatic. Accumulating evidence implicates the involvement of spinal glia in some neuropathic pain models. In this study, using a vincristine-evoked CNP rat model with obvious mechanical allodynia, we(More)
BACKGROUND Over-expression and increased activity of cyclooxygenase (COX)-2 induced by smoking has been implicated in the development of cancer. This study aimed to explore the interaction between smoking and functional polymorphisms of COX-2 in modulation of gastric cardia adenocarcinoma (GCA) risk. METHODS AND FINDINGS Three COX-2 polymorphisms,(More)