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Because of the randomness of biometric features, traditional methods cannot perform well in the encryption of fingerprint template. The Fuzzy Vault construct is a biometric cryptosystem which can bind the fingerprint features with the secret key, and give reliable protection to both of them. The performance of Fuzzy Vault is highly affected by the alignment(More)
Microarrays allowing simultaneous analysis of thousands of parameters can significantly accelerate screening of large libraries of pharmaceutical compounds and biomolecular interactions. For large-scale studies on diverse biomedical samples, reliable, label-free, and high-content microarrays are needed. In this work, using large-area plasmonic nanohole(More)
Therapies based on biologics involving delivery of proteins, DNA, and RNA are currently among the most promising approaches. However, although large combinatorial libraries of biologics and delivery vehicles can be readily synthesized, there are currently no means to rapidly characterize them in vivo using animal models. Here, we demonstrate high-throughput(More)
It is a very demanding task to design a reliable fingerprint matching approach with high accuracy and speed. An algorithm based on the novel structure combining the singular point with its neighborhood minutiae proposed in this paper can solve this problem efficiently. The structure introduced in this paper has two novel ideas as follows: First, we give an(More)
Synaptic function is affected in many brain diseases and disorders. Technologies for large-scale synapse assays can facilitate identification of drug leads. Here we report a 'synapse microarray' technology that enables ultra-sensitive, high-throughput and quantitative screening of synaptogenesis. Our platform enables the induction of synaptic structures in(More)
Recent studies on neuron imaging show that there is a strong relationship between the functional properties of a neuron and its morphology, especially its dendritic spine structures. However, most of the current methods for morphological spine classification only concern features in two-dimensional (2D) space, which consequently decreases the accuracy of(More)
Multiple lines of evidence indicate a strong relationship between Αβ peptide-induced neurite degeneration and the progressive loss of cognitive functions in Alzheimer disease (AD) patients and in AD animal models. This prompted us to develop a high content screening assay (HCS) and Neurite Image Quantitator (NeuriteIQ) software to quantify the loss of(More)
Myxococcus xanthus cells self-organize into periodic bands of traveling waves, termed ripples, during multicellular fruiting body development and predation on other bacteria. To investigate the mechanistic basis of rippling behavior and its physiological role during predation by this Gram-negative soil bacterium, we have used an approach that combines(More)