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Subfertility and defective folliculogenesis in female mice lacking androgen receptor.
TLDR
In vivo evidence is provided showing that AR plays an important role in female reproduction, with diminished endometrial growth in uteri in response to exogenous gonadotropins indicates that AR(-/-) females exhibit a luteal phase defect. Expand
Altered Glycosylation in Cancer: Sialic Acids and Sialyltransferases
TLDR
Evidence shows that altered ST expression have a significant correlation with oncogenesis, tumor progression, and lymph node metastases, and the functional roles of ST in cancer pathogenesis should be elucidated with the assistance of advanced molecular technology. Expand
Oestrogen‐induced epithelial–mesenchymal transition of endometrial epithelial cells contributes to the development of adenomyosis
TLDR
In adenomyosis, the serum E2 level was negatively correlated with E‐cadherin expression in the epithelial components of the eutopic endometrium andadenomyotic lesions, suggesting the involvement of oestrogen‐induced EMT in endometrial cells. Expand
Migraine Prevalence During Menopausal Transition
TLDR
The effect of menopausal transition on the frequency of migraine has never been the focus of a community‐based study and this work aims to change that. Expand
Interleukin-6 differentially regulates androgen receptor transactivation via PI3K-Akt, STAT3, and MAPK, three distinct signal pathways in prostate cancer cells.
TLDR
It is found that IL-6 could go through at least three distinct pathways to modulate the functions of androgen receptor (AR), a key transcriptional factor to control the prostate cancer growth. Expand
Hyperemesis gravidarum.
TLDR
It is recommended that early intervention and treatment of nausea and vomiting of pregnancy is needed to prevent progression to hyperemesis gravidarum, which is characterized by persistent vomiting, weight loss of more than 5%, ketonuria, electrolyte abnormalities, and dehydration, resulting in the diminishment of the woman's quality of life and significant contribution to health care costs and time lost from work. Expand
Abnormal Mammary Gland Development and Growth Retardation in Female Mice and MCF7 Breast Cancer Cells Lacking Androgen Receptor
TLDR
The data provide the first in vivo evidence showing that AR-mediated MAPK and ER activation may play important roles for mammary gland development and MCF7 breast cancer cell proliferation. Expand
Single-Port Compared With Conventional Laparoscopic-Assisted Vaginal Hysterectomy: A Randomized Controlled Trial
TLDR
Transumbilical two-channel single-port laparoscopic-assisted vaginal hysterectomy significantly decreases postoperative pain and analgesic use. Expand
Human Checkpoint Protein hRad9 Functions as a Negative Coregulator To Repress Androgen Receptor Transactivation in Prostate Cancer Cells
TLDR
The identification of hRad9, a key member of the checkpoint Rad protein family, as a coregulator to suppress androgen-AR transactivation in prostate cancer cells is reported, providing the first linkage between androgen -AR signals and radiation-induced responses. Expand
The relationship of self-reported sleep disturbance, mood, and menopause in a community study
TLDR
Both menopausal status and higher anxiety score were associated with poor sleep quality of midlife women in Taiwanese middle-aged women. Expand
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