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Platform technology owners often nurture their innovation ecosystems to seek complementary invention and exploit indirect network effects. In this study we examine whether participation in ecosystem partnership creates business value and impacts their business performance for small independent software vendors (ISVs) in the enterprise software industry, and(More)
During the development of the spinal cord, proliferative neural progenitors differentiate into postmitotic neurons with distinct fates. How cells switch from progenitor states to differentiated fates is poorly understood. To address this question, we studied the differentiation of progenitors in the zebrafish spinal cord, focusing on the differentiation of(More)
Popular online social networks (OSNs) like Facebook and Twitter are changing the way users communicate and interact with the Internet. A deep understanding of user interactions in OSNs can provide important insights into questions of human social behavior and into the design of social platforms and applications. However, recent studies have shown that a(More)
We describe an enhancer trap transgenic zebrafish line, ETvmat2:GFP, in which most monoaminergic neurons are labeled by green fluorescent protein (GFP) during embryonic development. The reporter gene of ETvmat2:GFP was inserted into the second intron of vesicular monoamine transporter 2 (vmat2) gene, and the GFP expression pattern recapitulates that of the(More)
This paper presents a general approach based on the shape similarity tree for non-sequential alignment across databases of multiple unstructured mesh sequences from non-rigid surface capture. The optimal shape similarity tree for non-rigid alignment is defined as the minimum spanning tree in shape similarity space. Non-sequential alignment based on the(More)
Question classification is one of the most important sub- tasks in Question Answering systems. Now question tax- onomy is getting larger and more fine-grained for better answer generation. Many approaches to question classifi- cation have been proposed and achieve reasonable results. However, all previous approaches use certain learning al- gorithm to learn(More)
The Period2 gene plays a key role in controlling circadian rhythm in mice. We report here that mice deficient in the mPer2 gene are cancer prone. After gamma radiation, these mice show a marked increase in tumor development and reduced apoptosis in thymocytes. The core circadian genes are induced by gamma radiation in wild-type mice but not in mPer2 mutant(More)
Cancer cells generally exhibit increased glycolysis for ATP generation (the Warburg effect) due in part to mitochondrial respiration injury and hypoxia, which are frequently associated with resistance to therapeutic agents. Here, we report that inhibition of glycolysis severely depletes ATP in cancer cells, especially in clones of cancer cells with(More)
Cancer cells exhibit increased glycolysis for ATP production due, in part, to respiration injury (the Warburg effect). Because ATP generation through glycolysis is less efficient than through mitochondrial respiration, how cancer cells with this metabolic disadvantage can survive the competition with other cells and eventually develop drug resistance is a(More)
A single nucleotide polymorphism (SNP) in the human mu-opioid receptor gene (OPRM1 A118G) has been widely studied for its association in a variety of drug addiction and pain sensitivity phenotypes; however, the extent of these adaptations and the mechanisms underlying these associations remain elusive. To clarify the functional mechanisms linking the OPRM1(More)