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Genome shuffling was used to improve the acetic acid tolerance of an ethanologenic yeast, Candida krusei GL560. A mutant, S4-3, was isolated and selected after four rounds of genome shuffling. It was found that the mutant S4-3 had a higher viability in the YNBX (yeast nitrogen base/xylose) medium with acetic acid and grew better in the YPD (yeast extract,(More)
Mixed lineage kinase domain-like protein (Mlkl) was recently found to interact with receptor interacting protein 3 (Rip3) and to be essential for tumor necrosis factor (TNF)-induced programmed necrosis (necroptosis) in cultured cell lines. We have generated Mlkl-deficient mice by transcription activator-like effector nucleases (TALENs)-mediated gene(More)
BACKGROUND To explore the potential role of natural-resistance-associated macrophage protein 1 (NRAMP1) gene, vitamin D receptor (VDR) gene, (human leukocyte antigen, (HLA-DRB1) HLA)-DRB1 gene, and HLA-DQB1 gene polymorphisms in susceptibility to tuberculosis (TB) in the Chinese Kazakh population. METHODS A case-control study was performed on the Chinese(More)
—Cross-project defect prediction (CPDP) has been deemed as an emerging technology of software quality assurance, especially in new or inactive projects, and a few improved methods have been proposed to support better defect prediction. However, the regular CPDP always assumes that the features of training and test data are all identical. Hence, very little(More)
We observe that a same rule set can induce very different memory requirement, as well as varying classification performance, when using various well known decision tree based packet classification algorithms. Worse, two similar rule sets, in terms of types and number of rules, can give rise to widely differing performance behaviour for a same classification(More)
Coenzyme Q10 (CoQ10) provides the energy for vital cellular functions and is known to act as an antioxidant. We conducted an open label study to examine the clinical effects of supplementation of the reduced form of CoQ10, ubiquinol, in addition to conventional glucose-lowering agents in patients with type 2 diabetes. Nine subjects (3 males and 6 females)(More)
Insect odorant binding proteins (OBPs) and chemosensory proteins (CSPs) play an important role in chemical communication of insects. Gene discovery of these proteins is a time-consuming task. In recent years, expressed sequence tags (ESTs) of many insect species have accumulated, thus providing a useful resource for gene discovery. We have developed a(More)
Thermoanaerobacter tengcongensis MB4 glucoamylase (TteGA) contains a catalytic domain (CD), which is structurally similar to eukaryotic GA, and a β domain (BD) with ambiguous function. Firstly, BD is found to be essential to TteGA activity because CD alone could not hydrolyze soluble starch. However, starch hydrolysis activity, similar to that of intact(More)
The inference of genes that are truly associated with inherited human diseases from a set of candidates resulting from genetic linkage studies has been one of the most challenging tasks in human genetics. Although several computational approaches have been proposed to prioritize candidate genes relying on protein-protein interaction (PPI) networks, these(More)
Context: Software defect prediction plays a crucial role in estimating the most defect-prone components of software, and a large number of studies have pursued improving prediction accuracy within a project or across projects. However, the rules for making an appropriate decision between within-and cross-project defect prediction when available historical(More)