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MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation.
TLDR
The results indicate that miR-188 is a key regulator of the age-related switch between osteogenesis and adipogenesis of BMSCs and may represent a potential therapeutic target for age- related bone loss.
miR‐148a regulates osteoclastogenesis by targeting V‐maf musculoaponeurotic fibrosarcoma oncogene homolog B
TLDR
It is found that miR‐148a is dramatically upregulated during osteoclastic differentiation of circulating CD14+ peripheral blood mononuclear cells (PBMCs) induced by macrophage colony stimulating factor (M‐CSF) and receptor activator of nuclear factor‐κB ligand (RANKL).
miR‐93/Sp7 function loop mediates osteoblast mineralization
TLDR
It is identified that miR‐93 was the most significantly downregulated miRNA during osteoblast mineralization and carried out its function through a novel miR•93/Sp7 regulatory feedback loop.
MiR‐503 Regulates Osteoclastogenesis via Targeting RANK
TLDR
It is reported that miR‐503 was markedly reduced in circulating progenitors of osteoclasts–CD14+ peripheral blood mononuclear cells (PBMCs) from postmenopausal osteoporosis patients compared with those from post menopausal healthy women.
Phenotypic Plasticity of Invasive Edge Glioma Stem-like Cells in Response to Ionizing Radiation
TLDR
It is reported that the invading edge and tumor core have two distinct types of glioma stem-like cells (GSCs) that resemble proneural (PN) and mesenchymal (MES) subtypes, respectively.
MicroRNA-1 inhibits proliferation of hepatocarcinoma cells by targeting endothelin-1.
TLDR
It is demonstrated that miR-1 could inhibit ET-1 expression to attenuate the proliferation of hepatoma cells and could be partially restored by exogenousET-1 treatment.
Sorafenib improves the survival of patients with advanced hepatocellular carcinoma: a meta-analysis of randomized trials
TLDR
This meta-analysis suggests that sorafenib-based chemotherapy is superior to placebo- based chemotherapy in terms of TPP and OS without increase in severe toxic effects.
FOXD1-ALDH1A3 Signaling Is a Determinant for the Self-Renewal and Tumorigenicity of Mesenchymal Glioma Stem Cells.
TLDR
A FOXD1-ALDH1A3 pathway is defined in controling the clonogenic and tumorigenic potential of MES GSC in glioblastoma tumors.
Bicluster and pathway enrichment analysis of HCV-induced cirrhosis and hepatocellular carcinoma.
TLDR
The results could aid in seeking of therapeutic targets for HCV-induced hepatocellular carcinoma through upregulating the pathways of ECM-receptor interaction, focal adhesion, cell adhesion molecules and other cancer-related pathways, and downregulatingThe pathways of "complement and coagulation cascades".
Glioma Cells Promote the Expression of Vascular Cell Adhesion Molecule-1 on Bone Marrow-Derived Mesenchymal Stem Cells: a Possible Mechanism for Their Tropism Toward Gliomas
TLDR
Findings suggested that glioma-induced change in VCAM-1 expression of BMSCs may play an important role in their tropism towards gliomas, and PI3K is associated with the signal transduction of this process.
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