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PURPOSE To develop a phase encoding reduction scheme based on compressed sensing (CS) for phase-encoded (1) H MR spectroscopic imaging (MRSI). MATERIALS AND METHODS Phantom and in vivo rat brain MRSI experiments were performed at 7 Tesla to examine the performance of CS approach and compare it with the full k-space acquisition. The CS undersampling was(More)
TJ0711 (1-[4-(2-methoxyethyl)phenoxy]-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanol) is a novel β-adrenoreceptor blocker with vasodilating activity. The aim of this study was to investigate the in vitro metabolic properties of TJ0711 from both qualitative and quantitative aspects using mouse, rat, dog, and human liver microsomes as well as rat hepatocytes.(More)
Soil and water loss has been a major environmental problem in the Danjiangkou Reservoir region where slope farming is commonly practiced but the local topography is hilly. As the core water region for the "South-to-North Water Transfer Project", certain measures should be implemented to ensure the safe of water quality. In consideration of the poor(More)
PURPOSE To develop a specialized multislice, single-acquisition approach to detect the metabolites of hyperpolarized (HP) [2-13 C]dihydroxyacetone (DHAc) to probe gluconeogenesis in vivo, which have a broad 144 ppm spectral range (∼4.6 kHz at 3T). A novel multiband radio-frequency (RF) excitation pulse was designed for independent flip angle control over(More)
The thermal environment of embryos differs significantly along a latitudinal cline, and the mechanism by which embryos respond to this geographic temperature variation has attracted increasing attention recently. Here, we carried out a common-garden experiment of egg incubation at two fluctuating temperature regimes to elucidate the latitudinal pattern and(More)
RF coil operation at the ultrahigh field of 7T is fraught with technical challenges that limit the advancement of novel human in vivo applications at 7T. In this work, a hybrid technique combining a microstrip transmission line and a lumped-element L-C loop coil to form a double-nuclear RF coil for proton magnetic resonance imaging and carbon magnetic(More)
Quantitative determination of the allele frequency of single-nucleotide polymorphism (SNP) in pooled DNA samples is a promising approach to clarify the relationships between SNPs and diseases. Here, we present such a simple, accurate, and inexpensive method for quantitative determining the allele frequency in pooled DNA samples. Three steps of DNA pooling,(More)
PURPOSE To develop a lump-element double-tuned common-mode-differential-mode (CMDM) radiofrequency (RF) surface coil with independent frequency tuning capacity for MRS and MRI applications. METHODS The presented design has two modes that can operate with different current paths, allowing independent frequency adjustment. The coil prototype was tested on(More)
PURPOSE To investigate whether diffusion magnetic resonance spectroscopy (MRS) can detect the extracellular matrix (ECM) degradation during intervertebral disc degeneration (IVDD) by the increased mobility of ECM macromolecules such as proteoglycans and collagens. METHODS Fresh bovine intervertebral discs were injected with papain solution to induce ECM(More)
PURPOSE Intramyocellular lipid (IMCL) droplets are dynamic organelles whose morphology reflects their vital roles in lipid synthesis, usage, and storage in muscle energy metabolism. To develop noninvasive means to measure droplet microstructure in vivo, we investigated the molecular diffusion behavior of IMCL with diffusion magnetic resonance spectroscopy.(More)