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This study investigated the ability of anaerobic periodontal bacteria to inactivate and resist killing by antimicrobial peptides through production of extracellular proteases. Antibacterial activities of peptides were assessed in a double-layer agarose diffusion assay, and MICs and MBCs were determined in broth microdilution assays. Culture supernates of(More)
Porphyromonas gingivalis is a gram-negative, black-pigmented anaerobe that has been associated with advanced periodontal disease. The genome of P. gingivalis has the potential to produce a number of virulence determinants including proteases, hemagglutinins, hemolysin, invasion-associated proteins, and products of the pathogenicity island ragAB; however,(More)
Experiments were made for the purpose of testing the reaction of protection against infection as a measure of potency of antimeningococcic serum. The results of the experiments were extremely variable and bore no relation to the quality of the sera as determined by the period of immunization of the horses from which they were obtained, or the indications of(More)
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