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Small-Colony Mutants of Staphylococcus aureus Allow Selection of Gyrase-Mediated Resistance to Dual-Target Fluoroquinolones
- X. Pan, Penelope J Hamlyn, R. Taléns-Visconti, F. Alovero, R. Manzo, L. Fisher
- Medicine, Biology
- Antimicrobial Agents and Chemotherapy
- 1 August 2002
It is proposed that small-colony mutations unbalance target sensitivities, perhaps through altered ATP or topoisomerase levels, such that gyrase becomes the primary drug target. Expand