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In Lafora disease (LD), the deficiency of either EPM2A or NHLRC1, the genes encoding the phosphatase laforin and E3 ligase, respectively, causes massive accumulation of less-branched glycogen inclusions, known as Lafora bodies, also called polyglucosan bodies (PBs), in several types of cells including neurons. The biochemical mechanism underlying the PB(More)
Non-nucleoside reverse-transcriptase inhibitors (NNRTIs) are one of the key components of antiretroviral drug regimens against human immunodeficiency virus type 1 (HIV-1) replication. (+)-calanolide A, which is purified from the rainforest plant Calophyllum, is an anti-HIV-1/ tuberculosis drug. In our previous study, a library of (+)-calanolide A was(More)
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