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The magnetization transfer contrast (MTC) technique was used in low-field-strength (0.1 T) magnetic resonance (MR) imaging of 28 patients with intracranial tumors. MTC images were generated with an off-resonance, low-power radio-frequency pulse applied during the interpulse delay period of a gradient-echo partial-saturation sequence (TR msec/TE msec =(More)
BACKGROUND Somatization is a clinical phenomenon characterized by multiple, medically unexplained somatic symptoms. The pathophysiology remains unknown. We aimed to test the hypothesis of a central nervous system dysfunction in the pathophysiology of this disorder. METHOD We studied 10 female patients diagnosed as having somatization disorder or(More)
Detection of early vascular changes indicated by lowered coronary flow reserve (CFR) would allow early treatment and prevention of atherosclerosis. The purpose of this study was to test whether it is possible to reproducibly measure CFR with transthoracic Doppler echocardiography (TTE) in healthy volunteers. We measured CFR using dipyridamole infusion in(More)
The time-dependent saturation transfer technique was used to measure the transfer of magnetization in several rat tissues at 0.1 T. The length of the saturation pulse was varied from 0 to 510 msec. The magnetization transfer contrast effect was characteristic for each type of tissue. A substantial reduction of image intensity was obtained in skeletal muscle(More)
Measures of arterial elasticity have been proposed as surrogate markers for asymptomatic atherosclerosis. We investigated the relations of serum lipoproteins, oxidized low-density lipoprotein (ox-LDL), and familial hypercholesterolemia (FH) to arterial elasticity among young men. As a marker of arterial elasticity we measured compliance in the thoracic(More)
PURPOSE Maps related to relative cerebral blood volume (rCBV) were generated with the use of the T1 effects produced by a low-dose bolus passage of gadopentetate dimeglumine. The T1 maps were evaluated in a tumor population and compared with rCBV maps obtained with T2-weighted measurements. METHODS Imaging was performed in 19 patients with suspected(More)
Functional magnetic resonance imaging exploits deoxygenated blood as an endogenous source for contrast in assessing local changes in tissue perfusion. Intrinsic changes in myocardial signal intensity were measured during dipyridamole induced coronary vasodilatation with T2*-weighted echo planar MRI in healthy volunteers. Concurrently, changes in flow(More)
In order to study the applicability of magnetization transfer contrast (MTC) to tissue differentiation, the determination of the magnetization transfer (MT) parameters of normal tissues is necessary for the evaluation of pathological conditions. The time-dependent saturation transfer technique was used to investigate the observed magnetization transfer(More)
PURPOSE To assess first-pass magnetic resonance (MR) imaging in the evaluation of perfusion impairment in a genetically homogeneous population of patients with hypertrophic cardiomyopathy (HCM) and the Asp175Asn mutation of the alpha-tropomyosin gene and to evaluate the association between hypertrophy and perfusion. MATERIALS AND METHODS Rest-stress(More)
Gadolinium-isothiocyanato-benzyl-diethylenetriamine pentaacetic acid (ITCB-DTPA-Gd), a derivative of Gd-DTPA, was multiply conjugated to bovine serum albumin (BSA). In the synthesis of BSA-(ITCB-DTPA-Gd) conjugate, none of the five carboxylate groups of DTPA is functionalized for protein-chelate linkage. The rationale for this modification is to improve the(More)