Pekka Marjamäki

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Dopamine D1 and D2 receptor binding was investigated in the caudate nucleus and putamen in 65 individuals ranging from 6 to 93 years of age. [3H]SCH 23390 and [3H]spiroperidol were used as ligands for D1 and D2 receptors, respectively. A full Scatchard analysis with several ligand concentrations was performed yielding Bmax and Kd values. The number of D1(More)
Brain nicotinic receptors were studied in the frontal cortex, temporal cortex, hippocampus and caudate nucleus in patients with Parkinson's disease (PD), Alzheimer's disease (AD) and control. The Bmax and Kd values of (-)-[3H]nicotine binding were determined with a Scatchard analysis. The number of nicotinic receptors declined both in PD and in AD patients(More)
To determine the lumped constant (LC), which accounts for the differences in the transport and phosphorylation between [18F]-2-fluoro-2-deoxy-d-glucose ([18F]FDG) and glucose, for [18F]FDG in human adipose tissue. [18F]FDG-PET was combined with microdialysis. Seven non-obese (29 ± 2 years of age, BMI 24 ± 1 kg/m2) and seven obese (age 32 ± 2 years of age,(More)
UNLABELLED 18F-labeled fluoroerythronitroimidazole (FETNIM) has been suggested as a marker of tumor hypoxia for use with PET. Our goal was to evaluate the pharmacokinetic properties of [18F]FETNIM in rats and analyze metabolites in human, dog, and rat plasma and urine. Metabolites in liver and tumor homogenates from tumor-bearing rats, as well as the(More)
Striatal dopamine reuptake sites were studied in brain samples from 14 Alzheimer's disease (AD) patients. A cocaine analogue, [3H]CFT (WIN 35,428, 2β-carbomethoxy-3β-(4-fluorophenyl)-tropane) was used as a radioligand to determine the number of [3H]CFT binding sites (Bmax) and their dissociation constant (Kd). In patients with AD the reduction in [3H]CFT(More)
Brain [3H]Met- and [3H]Leu-enkephalin binding was studied in patients with Alzheimer's disease (AD) and vascular dementia (VD), and in age-matched controls. Brain areas investigated were the internal and external globus pallidus, amygdala, hippocampus and temporal cortex. In AD, the binding of both enkephalins decreased in all brain areas examined, except(More)
Brain Met- and Leu-enk levels were investigated with radioimmunoassay and their binding to enkephalin receptors was studied with [3H]Met- and [3H]Leu-enkephalin in 56 human subjects (4-93 yr). Of the brain areas investigated, the head of the caudate nucleus and pallidum showed an age-associated decline for both Met- and Leu-enk content. In the substantia(More)
The muscarinic receptor subtypes determined by displacing [3H]quinuclidinyl benzylate by carbachol showed distinct profiles in Alzheimer's disease (AD) and in Parkinson's disease (PD). A decrease in the M2-receptor count was seen in the hippocampus in AD as compared to controls, while PD patients had unaltered binding. By contrast, PD patients had increased(More)
It is shown that the value of adhesion strength at the metallisation/polymer interface can be determined directly from a printed wiring board (PWB) by a pull-off method. However, careful optimisation of the test geometry is required. In particular, the mechanical properties of the substrate are important. The use of flexible substrate in the test results in(More)
Striatal dopamine D1 and D2 receptors were investigated in 49 patients with Parkinson's disease (PD) and 33 age-matched controls with [3H]SCH 23390 and [3H]spiroperidol as ligands respectively. A full Scatchard analysis giving Bmax and Kd values was performed. In the caudate nucleus, a small but significant decrease in the number of D1 and D2 receptors was(More)