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  • Maija Harrela, Hannu Koistinen, +8 authors Malla Seppälä
  • Biology, Medicine
  • The Journal of clinical investigation
  • 1996 (First Published: 1 December 1996)
  • We assessed the magnitude of the genetic component in the variation of circulating levels of insulin-like growth factors I and II (IGF-I and IGF-II), and their binding proteins IGFBP-1 and IGFBP-3 byContinue Reading
  • Riitta Koistinen, Maarit Angervo, Pekka E. Leinonen, T. Hakala, Markku Seppälä
  • Chemistry, Medicine
  • Clinica chimica acta; international journal of…
  • 1993 (First Published: 1 June 1993)
  • Different fractions of insulin-like growth factor-binding protein-1 (IGFBP-1) from anion exchange chromatography represent differently phosphorylated forms as demonstrated by protein kinase andContinue Reading
  • Tarja Kalme, Markku Seppälä, +6 authors Jaakko Tuomilehto
  • Medicine
  • The Journal of clinical endocrinology and…
  • 2005 (First Published: 1 March 2005)
  • Two binding proteins, SHBG and IGF-binding protein-1 (IGFBP-1), are both down-regulated by insulin and therefore could serve as potential indicators of the metabolic syndrome andContinue Reading
  • Maija Harrela, Qiaohua Qiao, +4 authors Pekka E. Leinonen
  • Medicine
  • Hormone and metabolic research = Hormon- und…
  • 2002 (First Published: 1 March 2002)
  • Insulin-like growth factor binding protein-1 (IGFBP-1) has been implicated in the development of cardiovascular disease, but it is not known whether IGFBP-1 is related to cardiovascular mortality. WeContinue Reading
  • C J Peter Eriksson, T V Widenius, Reino H. Ylikahri, Matti Härkönen, Pekka E. Leinonen
  • Chemistry, Medicine
  • The Biochemical journal
  • 1983 (First Published: 15 January 1983)
  • In experiments in which liver and testis freeze-stops were performed on pentobarbital-anaesthetized rats, ethanol (1.5 g/kg body wt.) reduced plasma testosterone concentration from 13.1 to 3.2Continue Reading