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INTRODUCTION Deregulated or excessive host immune responses contribute to the pathogenesis of sepsis. Toll-like receptor (TLR) signaling pathways and their negative regulators play a pivotal role in the modulation of host immune responses and the development of sepsis. The objective of this study was to investigate the association of variants in the TLR(More)
Alzheimer's disease (AD), one of the neurodegenerative disorders that may develop in the elderly, is characterized by the deposition of β‑amyloid protein (Aβ) and extensive neuronal cell death in the brain. Neuregulin‑1 (Nrg1)‑mediated intercellular and intracellular communication via binding to ErbB receptors regulates a diverse set of biological processes(More)
In this paper, we propose a novel hybrid multi-objective immune algorithm with adaptive differential evolution, named ADE-MOIA, in which the introduction of differential evolution (DE) into multi-objective immune algorithm (MOIA) combines their respective advantages and thus enhances the robustness to solve various kinds of MOPs. In ADE-MOIA, in order to(More)
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