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INTRODUCTION Deregulated or excessive host immune responses contribute to the pathogenesis of sepsis. Toll-like receptor (TLR) signaling pathways and their negative regulators play a pivotal role in the modulation of host immune responses and the development of sepsis. The objective of this study was to investigate the association of variants in the TLR(More)
In this paper, we propose a novel hybrid multi-objective immune algorithm with adaptive differential evolution, named ADE-MOIA, in which the introduction of differential evolution (DE) into multi-objective immune algorithm (MOIA) combines their respective advantages and thus enhances the robustness to solve various kinds of MOPs. In ADE-MOIA, in order to(More)
This study proposes a novel recombination operator, called hybrid crossover operator (HX), which is performed in gene level of chromosome to enhance the optimization performance of multi-objective evolutionary algorithms (MOEAs). The proposed HX operator combines the advantages of simulated binary crossover with local search ability and differential(More)
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