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A metabonomic study of hepatitis B-induced liver cirrhosis and hepatocellular carcinoma by using RP-LC and HILIC coupled with mass spectrometry.
Liver cirrhosis and hepatocellular carcinoma (HCC) are fatal sequelaes of chronic hepatitis B in China. The sera from HCC and cirrhosis were profiled by rapid resolution liquid chromatography coupled… Expand
Preanalytical aspects and sample quality assessment in metabolomics studies of human blood.
BACKGROUND Metabolomics is a powerful tool that is increasingly used in clinical research. Although excellent sample quality is essential, it can easily be compromised by undetected preanalytical… Expand
A support vector machine-recursive feature elimination feature selection method based on artificial contrast variables and mutual information.
- Xiaohui Lin, Fufang Yang, +7 authors Guowang Xu
- Chemistry, Medicine
- Journal of chromatography. B, Analytical…
- 1 December 2012
Filtering the discriminative metabolites from high dimension metabolome data is very important in metabolomics study. Support vector machine-recursive feature elimination (SVM-RFE) is an efficient… Expand
Metabolic characterization of hepatocellular carcinoma using nontargeted tissue metabolomics.
Hepatocellular carcinoma has a poor prognosis due to its rapid development and early metastasis. In this report, we characterized the metabolic features of hepatocellular carcinoma using a… Expand
Metabonomics study of liver cancer based on ultra performance liquid chromatography coupled to mass spectrometry with HILIC and RPLC separations.
In this study, urinary metabolites from liver cancer patients and healthy volunteers were studied by a metabonomic method based on ultra performance liquid chromatography coupled to mass… Expand
Serum metabolic profiling study of hepatocellular carcinoma infected with hepatitis B or hepatitis C virus by using liquid chromatography-mass spectrometry.
The objective of the present study was to explore the common and specific metabolic alterations of hepatocellular carcinoma (HCC) infected with hepatitis B virus (HBV) or hepatitis C virus (HCV).… Expand
Serum metabolic profiling and features of papillary thyroid carcinoma and nodular goiter.
Thyroid carcinoma is a common endocrine malignancy worldwide, accounting for approximately 1% of all diagnosed cancers and about 91.5% of the malignancies of head and neck. However, differentiating… Expand
Effects of pre-analytical processes on blood samples used in metabolomics studies
- Peiyuan Yin, R. Lehmann, Guowang Xu
- Computer Science, Medicine
- Analytical and Bioanalytical Chemistry
- 4 March 2015
We present a review of the preanalytical phase of liquid chromatography–mass spectrometry-driven metabolomics analysis of body fluids. Expand
Pseudotargeted metabolomics method and its application in serum biomarker discovery for hepatocellular carcinoma based on ultra high-performance liquid chromatography/triple quadrupole mass…
Untargeted analysis performed using full-scan mass spectrometry (MS) coupled with liquid chromatography (LC) is commonly used in metabolomics. Although they are commonly employed, full-scan MS… Expand
Comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry for metabonomics: Biomarker discovery for diabetes mellitus.
Comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry (GCxGC-TOFMS) coupled with pattern recognition methods was applied to analyze plasma from diabetic patients and… Expand