Peixun Zhang

Learn More
OBJECTIVE To explore the possibilities of bone marrow stromal cells (MSCs) to adopt Schwann cell phenotype in vitro and in vivo in SD rats. METHODS MSCs were obtained from tibia and femur bone marrow and cultured in culture flasks. Beta-mercaptoethanol followed by retinoic acid, forskolin, basic-FGF, PDGF and heregulin were added to induce differentiation(More)
To describe the rule of the Schwann cell proliferation after peripheral nerve injury in detail and to discover the effect of neuroanastomosis, the model of rat sciatic injury was made, with neuroanastomosis on the left side and right side untreated. Then the materials were drawn the 24th hour, 48th hour, 4th day, 7th day, 14th day, 21st day after surgery.(More)
Effects of Epimedium extract and its constituent icariin on peripheral nerve repair were investigated in a crush injury rat model. Animals were divided into four groups: sham, control, Epimedium extract, and icariin groups. At postoperative weeks 1, 2, 4, and 8, nerve regeneration and functional recovery were evaluated by sciatic functional index (SFI),(More)
To investigate the possibility of constructing artificial peripheral nerves using de-acetyl chitin conduit, the sciatic nerves defect model was built at left legs in SD rats. They were divided into 3 groups randomly: group A: nerve graft in situ (n = 12, gap distance 10 mm); group B: biological chitin conduit bridging the peripheral nerve defect (n = 12,(More)
Based on the research on small gap bridging peripheral nerve injury in SD rats, we decided to investigate the histological analysis possibility of bridging peripheral nerve injury with small gap using a de-acetyl chitin conduit in primate. Median nerves of 8 rhesus monkeys were cut at 2 cm above the elbow, and the right sides were subjected to small gap (2(More)
OBJECTIVE To evaluate the long-term results of the use of nerve growth factor (NGF)-loaded poly-D, L-lactide-co-glycolide (PLGA) microspheres for improve nerve regeneration with small gap tubulization. METHODS NGF microspheres were prepared by a modified W/O/W emulsion solvent evaporation method. Forty-eight male SD rats were separated into 4 groups and(More)
To investigate the changes of calcitonin gene-related peptide (CGRP) in rat's blood plasma, spinal anterior motorneuron, and dorsal root ganglion (DRG) after fractures combined with central or peripheral nerve injuries and its influence on fracture healing, 72 healthy adult SD rats (male or female) were divided into 4 groups (18 rats in each group): group(More)
Spinal cord injury (SCI) refers to the damage of spinal cord's structure and function due to a variety of causes. At present, many scholars have confirmed that apoptosis is the main method of secondary injury in spinal cord injury. In view of understanding the function of PI3K/Akt pathway on spinal cord injury, this study observed the temporal variation of(More)
The effects of the distal nerve degeneration on the regeneration of the collateral sprouts from the proximal nerve stump have been examined. The delayed cross-suture anastomosis technique was used in which the tibial nerve was denervated for 0-8 weeks before cross-suture of the freshly axotomized common peroneal and chronically denervated TIB nerve stumps.(More)
OBJECTIVE To discuss the efficacy of total elbow replacement in the treatment of complex distal humeral fractures. METHODS From May 2005 to October 2008 12 patients were retrospectively studied who were diagnosed complex fractures of the distal humerus and treated by total elbow replacement (Coonrad-Marrey). The mean age was 60 years old, the mean(More)