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Microbial fermentations and bioconversion promise to revolutionize the conventional extraction of resveratrol from natural plant sources. However, the development of efficient and feasible microbial processes remains challenging. Current fermentation strategies often require supplementation of expensive phenylpropanoic precursors and two separate(More)
UNLABELLED Phenylpropanoids are phytochemicals produced by some plants and possess a wide variety of biological activities. These compounds exist in plants in low amounts. Production of them in genetically engineered microorganisms has many advantages. A majority of functional phenylpropanoids are toxic to microbial hosts. Export of these compounds may(More)
Production of organic acids by microorganisms is of great importance for obtaining building-block chemicals from sustainable biomass. Extracellular accumulation of organic acids involved a series of transporters, which play important roles in the accumulation of specific organic acid while lack of systematic demonstration in eukaryotic microorganisms. To(More)
Augmented reality is a variation of virtual reality. It allows the user to see computer generated virtual objects superimposed upon the real world through the use of some kind of see-through head-mounted display. Human users of such system can interact with the virtual world and have additional information, such as character description of physical objects(More)
The computational cost of a collision detection (CD) algorithm on polygonal surfaces depends highly on the complexity of the models. A novel "locally refined" approach is introduced in this paper for fast CD in haptic rendering applications, e.g. haptic surgery and haptic sculpture simulations. Exact interference detections are performed on proposed locally(More)
This paper presents a novel approach for navigating in a Panorama-Based Virtual Environment (PBVE). A PBVE was constructed for the arbitrary view synthesis when navigating. Uses can interact with PBVE through augmented 3D graphic objects. Unlike traditional imagebased virtual environment (VE) systems in which the functions of presenting 3D geometry and(More)
Augmented Reality (AR) is a variation of virtual reality. It allows the user to see computer generated virtual objects superimposed upon the real world through the use of some kind of see-through headmounted display. Human users of such system can interact with the virtual world and have additional information, such as character description of physical(More)
We introduce a novel approach, multiresolution collision detection, for fast and exact interference detection on continuous level-of-detail (LOD) representations of arbitrary triangle meshes undergoing rigid-body motion. A new algorithm, active bounding tree (AB-Tree), is presented to accelerate interference queries of three-dimensional models, which(More)
In the phenylpropanoid production process, p-coumaric acid is the most important intermediate metabolite. It is generally accepted that the activity of tyrosine ammonia-lyase (TAL), which converts l-tyrosine to p-coumaric acid, represents the rate-limiting step. Therefore, an error-prone PCR-based random mutagenesis strategy was utilized for screening(More)