Peiqun Zhang

Learn More
Many studies have found that mercury (Hg) exposure is associated with selenium (Se) accumulation in vivo. However, human studies are limited. To study the interaction between Se and Hg, we investigated the total Se and Hg concentrations in body fluids and serum Se-containing proteins in individuals exposed to high concentrations of Hg. Our objective was to(More)
BACKGROUND Mercury is a ubiquitous and highly toxic environmental pollutant. In this study, we evaluated the relationship between mercury exposure and oxidative stress, serum and urinary mercury concentrations, oxidative DNA damage, and serum redox status in chronically mercury-exposed persons compared with healthy controls. METHODS We measured urinary(More)
The subcellular localization of Se and Hg and their cytosolic binding proteins, including cellular oxidative status, in porcine liver and kidney have been studied by using samples from a chronic Hg-contaminated area and a non-Hg-contaminated area. Coaccumulation and redistribution of Se and Hg in subcellular fractions due to mercury exposure were found. The(More)
Synchrotron radiation X-ray fluorescence (SRXRF) spectroscopy is an advanced method of quantitative multielemental analysis with space resolution of several microm and sensitivities in the microg g(-1) range. It can be used for keeping track of trace elements after an electrophoretic separation of biological samples. In this paper, proteins in human liver(More)
Activable enriched stable isotopes can play a unique role in studies of nutritional status, metabolism, absorption rates, and bioavailability of minerals. As a practical example, eight juvenile athletes were selected to test the absorption rates of iron during training and non-training periods by enriched stable isotope of Fe-58 (enriched degree: 51.1%) via(More)
Selenium is an important and essential trace element to living systems. In the article, two methods of instrumental neutron activation analysis and hydride generation-atomic fluorescence spectrometry were applied to determine Se in biological samples and the accuracy was evaluated by several reference materials. The subcellular distribution of selenium in(More)
Ten male Wistar rats were intravenously injected with a single approximately physiological dose of enriched stable isotopic Cr-50 tracer solution (200 ng (50)Cr(3+)/100 g body wt). The fundamental distribution patterns of the chromium-containing proteins in the nucleic, mitochondrial, lysosomal, microsomal, and cytosolic subcellular fractions of the rat(More)
The amounts of the 19 elements As, Br, Ca, Cd, Ce, Co, Cr, Cs, Fe, K, La, Mo, Na, Rb, Sb, Sc, Se, Sm, and Zn in 92 lyophilized autopsy human liver samples from normal subjects have been analyzed by instrumental neutron-activation analysis (INAA). For intercomparison and quality control ten samples were independently analyzed in two institutes, the Institute(More)
To investigate the roles of essential trace element selenium and cellular antioxidative systems in human hepatocellular carcinoma, we analyzed cellular distribution of selenium and assayed cytosolic and mitochondrial superoxide dismutase, glutathione peroxidase, thioredoxin reductase, glutathione and total protein thiols in 10 control healthy subjects, 6(More)
The neutron activation analysis, γ coincidence spectroscopy, nondispersive hydrogen flame atomic fluorescence spectroscopy, and Mössbauer spectrometry were used to study the low-selenium environment of the Exi Autonomous Prefecture, a well-known Keshan disease region. The Se contents in the soil samples there range from 0.075–0.18 mg/kg with the average of(More)
  • 1